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A Phase 1 Trial of Intravenous Boronophenylalanine-Fructose Complex in Patients with Glioblastoma Multiforme

  • R. Bergland
  • E. Elowitz
  • J. A. Coderre
  • D. Joel
  • M. Chadha

Abstract

Seven patients with glioblastoma multiforme received 2-hour intravenous infusions of p-boronophenylalanine (BPA) prior to craniotomy. The BPA was solubilized for injection by complexation with fructose. Administered BPA doses were 100mg BPA/kg (n=1), 130 mg BPA/kg (n=5) and 170 mg BPA/kg (n=1). The boron concentration in blood was proportional to the administered dose. The boron concentrations in scalp were 1-2 times higher than the corresponding boron concentration in the blood. The boron concentrations in the tumor (range, 11–26µg 10B/g) were from 1–4 times the corresponding levels in the blood.

Keywords

Boron Concentration Biodistribution Study Boron Neutron Capture Therapy Brookhaven National Laboratory Prompt Gamma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • R. Bergland
    • 1
  • E. Elowitz
    • 1
  • J. A. Coderre
    • 2
  • D. Joel
    • 2
  • M. Chadha
    • 3
  1. 1.Departments of NeurosurgeryBeth Israel Medical CenterNew YorkUSA
  2. 2.Medical DepartmentBrookhaven National LaboratoryUptonUSA
  3. 3.Radiation OncologyBeth Israel Medical CenterNew YorkUSA

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