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Boron Neutron Capture Therapy for Malignant Brain Tumors in Children

  • Yoshinobu Nakagawa
  • Kyonghon Pooh
  • Teruyoshi Kageji
  • Katsuji Kitamura
  • Hisao Komatsu
  • Fumio Tsuji
  • Hiroshi Hatanaka
  • Takashi Minobe

Abstract

Radiation therapy is used as a treatment for malignant brain tumors not only in adult cases but also in children. Conventional radiotherapy is effective for certain kinds of tumor. However, irradiation of brain tumors in small children especially those less than 5 years old, is associated with marked side effects including sequelae such as mental retardation, hormonal deficiency, and bone marrow suppression which may appear up to several years after the treatment. Boron neutron capture therapy (BNCT) is based on the nuclear reaction between boron-10 and thermal neutrons 2.3). The reaction occurs mainly in the tumor cells and the alpha particles produced from the reaction kill only the tumor cells4). Normal cells around the tumor receive little radiation effect. BNCT can therefore be considered as an intracellular internal radiation therapy and an ideal treatment for brain tumors in children 12).

Keywords

Thermal Neutron Boron Concentration Malignant Brain Tumor Boron Neutron Capture Therapy Gold Wire 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yoshinobu Nakagawa
    • 1
  • Kyonghon Pooh
    • 1
  • Teruyoshi Kageji
    • 1
  • Katsuji Kitamura
    • 1
  • Hisao Komatsu
    • 1
  • Fumio Tsuji
    • 2
  • Hiroshi Hatanaka
    • 3
  • Takashi Minobe
    • 4
  1. 1.Department of Neurosurgery and AnesthesiologyNational Kagawa Children’s HospitalKagawa 765Japan
  2. 2.Department of AnesthesiologyNational Okayama HospitalJapan
  3. 3.Department of NeurosurgeryJapan
  4. 4.Anesthesiology of Teikyo UniversityJapan

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