Chemical Properties of p-, m-, o-Boronophenylalanine
p-Boronophenylalanine (p-BPA)-fructose complex has been used for Boron Neutron Capture Therapy (BNCT) of malignant melanoma.1,2 o- and m-Boronophenylalanine (o- and m-BPA) are the isomers of p-BPA, and it is interesting to study the relationship between the chemical properties and incorporation of boron into malignant cells. We have already reported the synthesis of o-BPA and m-BPA.3 In this paper we will describe the chemical properties of these three structural isomers, and some biological uptake results.
KeywordsMelanoma Cell Chemical Species Boron Atom Boronic Acid Boron Neutron Capture Therapy
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