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Chemical Properties of p-, m-, o-Boronophenylalanine

  • Kazuo Yoshino
  • Nobuya Watanabe
  • Hiroaki Takahashi
  • Shinji Watanabe
  • Yoshihiro Mori
  • Masamitsu Ichihashi
  • Hidetake Kakihana
  • Yutaka Mishima

Abstract

p-Boronophenylalanine (p-BPA)-fructose complex has been used for Boron Neutron Capture Therapy (BNCT) of malignant melanoma.1,2 o- and m-Boronophenylalanine (o- and m-BPA) are the isomers of p-BPA, and it is interesting to study the relationship between the chemical properties and incorporation of boron into malignant cells. We have already reported the synthesis of o-BPA and m-BPA.3 In this paper we will describe the chemical properties of these three structural isomers, and some biological uptake results.

Keywords

Melanoma Cell Chemical Species Boron Atom Boronic Acid Boron Neutron Capture Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Kazuo Yoshino
    • 1
  • Nobuya Watanabe
    • 1
  • Hiroaki Takahashi
    • 1
  • Shinji Watanabe
    • 1
  • Yoshihiro Mori
    • 1
  • Masamitsu Ichihashi
    • 2
  • Hidetake Kakihana
    • 3
  • Yutaka Mishima
    • 4
  1. 1.Department of Chemistry Faculty of ScienceShinshu UniversityAsahi Matsumoto 390Japan
  2. 2.Kobe University School of MedicineKobe 650Japan
  3. 3.Energy Research CenterTsuruga 914Japan
  4. 4.Mishima Institute for Dermatological ResearchMishima Skin ClinicKobe 657Japan

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