Relationships of Cell Biology to Therapy in Childhood Leukemia

  • A. Thomas Look
  • Dorothy L. Williams
  • Joseph V. Simone

Abstract

As effective therapy for childhood acute leukemia developed, distinct prognostic subgroups of patients became apparent. Initially, two broad categories of prognostic features were recognized--morphologic and clinical. The separation of myeloid and lymphoid cell types by relatively crude methods of analysis was followed by more detailed classification with use of a variety of cytochemical stains. Clinical features were essentially those reflecting the volume and extent of leukemia, that is, the initial leukocyte count as well as the age and race of the patients (1). A long list of other features has been proposed to have prognostic significance, including serologic, biochemical, anthropomorphic, nutritional and psychosocial factors. However, the first prognostic feature with the potential for systematic biologic exploration was the discovery of T-cell features on the surface of leukemic cells of patients who responded poorly to therapy (2). This stimulated a surge of important clinical and basic research to categorize acute lymphoblastic leukemia (ALL) by the features of cells held in common with differentiation markers of normal lymphoid cells.

Keywords

Lymphoma Tyrosine Leukemia Oncol Cyclophosphamide 

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References

  1. 1.
    J. V. Simone, Prognostic Factors in Childhood Acute Lymphocytic Leukemia, Adv. Biosci. 14: 27 (1973).Google Scholar
  2. 2.
    L. Sen and L. Borella, Clinical Importance of Lymphoblasts with T Markers in Childhood Acute Leukemia, N. Eng. J. Med. 292: 828 (1975).CrossRefGoogle Scholar
  3. 3.
    A. T. Look, S. L. Melvin, D. L. Williams, M. Brodeur, G. V. Dahl, D. K. Kalwinsky, S. B. Murphy, and A. M. Mauer, Aneuploidy and Percentage of S-phase Cells Determined by Flow Cytometry Correlate with Cell Phenotype in Childhood Acute Leukemia, Blood 60: 959 (1982).PubMedGoogle Scholar
  4. 4.
    B. Barlogie, M. N. Raber, J. Schumann, T. S. Johnson, B. Drewinko, D. E. Swartzendruber, W. Göhde, M. Andreeff, and E. J. Freireich, Flow Cytometry in Clinical Cancer Research, Cancer Res. 43: 3982 (1983).PubMedGoogle Scholar
  5. 5.
    Third Internationl Workshop on Chromosomes in Leukemia, 1980: Clinical Significance of Chromosomal Abnormalities in Acute Lymphoblastic Leukemia, Cancer Genet. Cytogenet. 4: 111 (1981).Google Scholar
  6. 6.
    L. M. Secker-Walker, S. D. Lawler, and R. M. Hardisty, Prognostic Implications of Chromosomal Findings in Acute Lymphoblastic Leukemia at Diagnosis, Brit. Med. J. 2: 1529 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    L. M. Secker-Walker, G. J. Swansbury, R. M. Hardisty, S. E. Sallan, O. M. Garson, M. Sakurai, and S. D. Lawler, Cytogenetics of Acute Lymphoblastic Leukemia in Children as a Factor in the Prediction of Long-term Survival, Br. J. Haematol. 52: 389 (1982).PubMedCrossRefGoogle Scholar
  8. 8.
    Third International Workshop on Chromosomes in Leukemia. Chromosomal Abnormalities and their Clinical Significance in Acute Lymphoblastic Leukemia, Cancer Res. 43: 868 (1983).Google Scholar
  9. 9.
    D. L. Williams, A. T. Look, S. L. Melvin, P. K. Roberson, G. Dahl, T. Flahe, and S. Stass, New Chromosomal Translocations Correlate with Specific Immunophenotypes of Childhood Acute Lymphoblastic Leukemia, Cell 36: 101 (1984).PubMedCrossRefGoogle Scholar
  10. 10.
    J. D. Rowley, Identification of the Constant Chromosome Regions Involved in Human Hematologic Malignant Disease, Science 216: 749 (1982).PubMedCrossRefGoogle Scholar
  11. 11.
    D. L. Williams, A. Harris, K. J. Williams, M. J. Brosius, and W. Lemonds, A Direct Bone Marrow Chromosome Technique for Acute Lymphoblastic Leukemia, Cancer Genet. Cytogenet. 13: 239 (1984).PubMedCrossRefGoogle Scholar
  12. 12.
    D. L. Williams, S. Raimondi, G. Rivera, S. George, C. T. Berard, and S. B. Murphy, Presence of Clonal Chromosome Abnormalities in Virtually All Cases of Acute Lymphoblastic Leukemia, N. Eng. J. Med. 313: 640 (1985).Google Scholar
  13. 13.
    J. J. Punis, Recurrent Chromosomal Defects are Found in Most Patients with Acute Nonlymphocytic Leukemia, Cancer Genet. Cytogenet. 11: 125 (1984).CrossRefGoogle Scholar
  14. 14.
    G. Klein, Specific Chromosomal Translocations and the Genesis of B-cellDerived Tumors in Mice and Man, Cell 32: 311 (1983).PubMedCrossRefGoogle Scholar
  15. 15.
    I. T. Magrath and J. L. Ziegler, Bone Marrow Involvement in Burkitt’s Lymphoma and its Relationship to Acute B-cell Leukemia, Leuk. Res. 4: 33 (1979).CrossRefGoogle Scholar
  16. 16.
    G. Manolov and Y. Manolova, Marker Band in One Chromosome 14 from Burkitt Lymphomas, Nature 237: 33 (1972).PubMedCrossRefGoogle Scholar
  17. 17.
    R. Taub, I. Kirsch, C. Morton, G. Lenoir, D. Swan, S. Tronich, S. Aaronson, and P. Leder, Translocation of the c-myc Gene into the Immunoglobulin Heavy Chain Locus in Human Burkitt Lymphoma and Murine Plasmacytoma Cells, Proc. Natl. Acad. Sci. U.S.A. 79: 7837 (1982).PubMedCrossRefGoogle Scholar
  18. 18.
    R. Dalla-Favera, S. Martinotti, and R. C. Gallo, Translocation and Rearrangements of the c-myc Oncogene Locus in Human Undifferentiated B-cell Lymphomas, Science 219: 963 (1983).PubMedCrossRefGoogle Scholar
  19. 19.
    J. Erikson, A. Ar-Rushdi, H. L. Drwinga, P. C. Nowell, and C. M. Croce, Transcriptional Activation of the Translocated c-myc Oncogene in Burkitt Lymphoma, Proc. Natl. Acad. Sci. U.S.A. 80: 820 (1983).PubMedCrossRefGoogle Scholar
  20. 20.
    J. M. Adams, S. Georndakis, E. Webb, L. M. Corcoran, and S. Cory, Cellular myc Oncogene is Altered by Chromosome Translocation to an Immunoglobulin Locus in Murine Plasma Cytomas and is Rearranged Similarly in Human Burkitt Lymphomas, Proc. Nat].. Acad. Sci. U.S.A. 80: 1982 (1983).Google Scholar
  21. 21.
    R. Taub, C. Moulding, J. Battey, W. Murphy, T. Vasicek, G. M. Lenoir, and P. Leder, Activation and Somatic Mutation of the Translocated c-myc Gene in Burkitt Lymphoma Cells, Cell 36: 339 (1984).PubMedCrossRefGoogle Scholar
  22. 22.
    T. H. Rabbitts, A. Forster, P. Hamlyn, and R. Baer, Effect of Somatic Mutation within Translocated c-myc Genes in Burkitt’s Lymphoma, Nature 309: 592 (1984).PubMedCrossRefGoogle Scholar
  23. 23.
    R. Taub, K. Kelly, J. Battey, S. Latt, G. M. Lenoir, U. Tantravahi, Z. Tu, and P. Leder, A Novel Alteration in the Structure of an Activated c-myc Gene in a Variant t(2;8) Burkitt Lymphoma, Cell 37: 511 (1984).PubMedCrossRefGoogle Scholar
  24. 24.
    U. Siebenlist, L. Henninghausen, J. Battey, and P. Leder, Chromatin Structure and Protein Binding in the Putative Regulatory Region of the c-myc Gene in Burkitt Lymphoma, Cell 37: 381 (1984).PubMedCrossRefGoogle Scholar
  25. 25.
    K. Kelly, B. H. Cochran, C. D. Stiles, and P. Leder, Cell-specific Regulation of the c-myc Gene by Lymphocyte Mitogens and Platelet-derived Growth Factor, Cell 35: 603 (1983).PubMedCrossRefGoogle Scholar
  26. 26.
    H. Persson, L. Henninghausen, R. Taub, W. DeGrado, and P. Leder, Antibodies to Human c-myc Oncogene Product: Evidence of an Evolutionarily Conserved Protein Induced during Cell Proliferation, Science 225: 687 1984 ).PubMedCrossRefGoogle Scholar
  27. 27.
    W. S. Hayward, B. G. Neel, and S. M. Astrin, Activation of a Cellular one Gene by Promoter Insertion in ALV-induced Lymphoid Leukosis, Nature 290: 475 (1981).PubMedCrossRefGoogle Scholar
  28. 28.
    J. Erikson, D. L. Williams, J. Finan, P. C. Nowell, and C. M. Croce, Locus of the Alpha-chain of the T-cell Receptor is Split by Chromosome Translocation in T-cell Leukemias, Science 229: 784 (1985).PubMedCrossRefGoogle Scholar
  29. 29.
    W. H. Lewis, E. E. Michalopoulos, D. L. Williams, M. M. Minden, and T. W. Mak, Breakpoints in the Human T-cell Antigen Receptor Alpha-chain Locus in Two T-cell Leukemia Patients with Chromosomal Translocations, Nature 317: 544 (1985).PubMedCrossRefGoogle Scholar
  30. 30.
    A. J. Carroll, W. M. Crist, R. T. Parmley, M. Roper, M. D. Cooper, and W. H. Finley, Pre-B Cell Leukemia Associated with Chromosome Translocation, Blood 63: 721 (1984).PubMedGoogle Scholar
  31. 31.
    S. J. Korsmeyer, A. Arnold, A. Bakhshi, J. V. Ranetch, U. Siebenlist, P. A. Hieter, S. O. Sharrow, T. W. LeBien, J. K. Kersey, D. Q. Poplack, P. Leder, and T. A. Waldmann, Immunoglobulin Gene Rearrangement and Cell Surface Antigen Expression in Acute Lymphocytic Leukemias of T-cell and B-cell Precursor Origins, J. Clin. Invest. 71: 301 (1983).PubMedCrossRefGoogle Scholar
  32. 32.
    J. D. Rowley, A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukemia Identified by Quinacrine Fluorescence and Giemsa Staining, Nature 243: 290 (1973).PubMedCrossRefGoogle Scholar
  33. 33.
    J. D. Rowley, Biological Implications of Consistent Chromosome Rearrangements in Leukemia and Lymphoma, Cancer Res. 44: 3159 (1984).PubMedGoogle Scholar
  34. 34.
    K. Jain, Z. Arlin, R. Mertelsmann, T. Gee, S. Kempui, B. Koziner, A. Middleton, S. Jhanwar, R. Chaganti, and B. Clarkson, Philadelphia Chromosome and Terminal Transferase-positive Acute Leukemia: Similarity of Terminal Phase of Chronic Myelogenous Leukemia and de novo Acute Presentation, J. Clin. Oncol. 1: 669 (1983).PubMedGoogle Scholar
  35. 35.
    P. J. Fialkow and J. W. Singer, Tracing Development and Cell Lineages in Human Hemopoietic Neoplasia, in: “Leukemia,” I. L. Weissman, ed., Springer Verlag, Berlin, in press (1986).Google Scholar
  36. 36.
    G. Janossy, R. K. Woodruff, M. J. Pippard, G. Prentice, A. V. Hoffbrand, A. Paxton, T. A. Lister, C. Bunch, and M. F. Greaves, Relation of “Lymphoid” Phenotype and Response to Chemotherfpy Incorporating Vincristine-Prednisolone in the Acute Phase of Ph -positive Leukemia, Cancer 43: 426 (1979).PubMedCrossRefGoogle Scholar
  37. 37.
    G. Janossy, M. Roberts, and M. F. Greaves, Target Cell in Chronic Myeloid Leukemia and its Relationship to Acute Lymphoid Leukemia, Lancet 2: 1058 (1976).PubMedCrossRefGoogle Scholar
  38. 38.
    K. J. Roozendaal, H. J. van der Reijden, and J. P. Geraedts, Philadelphia Chromosome Positive Acute Lymphoblastic Leukaemia with T-cell Characteristics, Br. J. Haematol. 47: 145 (1981).PubMedCrossRefGoogle Scholar
  39. 39.
    J. D. Griffin, R. Tantravahi, G. P. Canellos, J. S. Wisch, E. L. Rein-herz, G. Sherwood, R. P. Beneridge, J. F. Daley, H. Lane, and S. F. Schlossuran, T-cell Surface Antigens in a Patient with Blast Crisis of Chronic Myeloid Leukemia, Blood 61: 640 (1983).PubMedGoogle Scholar
  40. 40.
    D. Catovsky, Ph -positive Acute Leukemia and Chronic Granulocytic Leukemia: One or Two Diseases? Br. J. Haematol. 42: 493 (1979).PubMedCrossRefGoogle Scholar
  41. 41.
    A. Klein, A. G. van Kessel, G. Grosveld, C. R. Bartram, A. Hagemeijer, D. Bootsma, N. K. Spurr, N. Heisterkamp, J. Groffen, and J. R. Stephenson, A Cellular Oncogene is Translocated to the Philadelphia Chromosome in Chronic Myelocytic Leukaemia, Nature 300: 765 (1982).PubMedCrossRefGoogle Scholar
  42. 42.
    N. Heisterkamp, J. R. Stephenson, J. Groffen, P. F. Hansen, A. de Klein, C. R. Bartram, and G. Grosveld, Localization of the c-abl Oncogene Adjacent to a Translocation Breakpoint in Chronic Myelocytic Leukaemia, Nature 306: 239 (1983).PubMedCrossRefGoogle Scholar
  43. 43.
    J. Groffen, J. R. Stephenson, N. Heisterkamp, A. de Klein, C. R. Bartram, and G. Grosveld, Philadelphia Chromosomal Breakpoints are Clustered within a Limited Region, bcr, on Chromosome, Cell 36: 93 (1984).PubMedCrossRefGoogle Scholar
  44. 44.
    N. Heisterkamp, K. Stam, J. Groffen, A. de Klein, and G. Grosveld1 Structural Organization of the bcr Gene and its Role in the Ph Translocation, Nature 315: 758 (1985).Google Scholar
  45. 45.
    R. P. Gale and E. Canaani, An 8-kilobase abl RNA Transcript in Chronic Myelogenous Leukemia, Proc. Natl. Acad. Sci. U.S.A. 81: 5648 (1984).PubMedCrossRefGoogle Scholar
  46. 46.
    E. Canaani, R. P. Gale, D. Steiner-Saltz, A. Berrebi, E. Aghai, and E. Januszewicz, Altered Transcription of an Oncogene in Chronic Myeloid Leukaemia, Lancet 2: 593 (1984).CrossRefGoogle Scholar
  47. 47.
    S. J. Collins, I. Kubonishi, I. Miyoshi, and M. T. Groudine, Altered Transcription of the c-abl Oncogene in K-562 and Other Chronic Myelogenous Leukemia Cells, Science 225: 72 (1984).PubMedCrossRefGoogle Scholar
  48. 48.
    K. Starr, Jr., N. Heisterkamp, G. Grosveld, A. de Klein, R. S. Verma, M. Coleman, H. Dosik, and J. Groffen, Evidence of a New Chimeric brc/c-abl mRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome, N. Eng. J. Med. 313: 1429 (1985).CrossRefGoogle Scholar
  49. 49.
    J. B. Konopka, S. M. Watanabe, and O. N. Witte, An Alteration of the Human c-abl Protein in K562 Leukemia Cells Unmasks Associated Tyrosine Kinase Activity, Cell 37: 1035 (1984).PubMedCrossRefGoogle Scholar
  50. 50.
    W. Kloetzer, R. Kurzrock, L. Smith M. Talpaz, M. Spiller, J. Gutterman, and R. Arlinghaus, The Human Cellular abl Gene Product in the Chronic Myelogenous Leukemia Cell Line K562 has an Associated Tyrosine Protein Kinase Activity, Virology 140: 230 (1985).PubMedCrossRefGoogle Scholar
  51. 51.
    C. D. Bloomfield, L. L. Lindquist, D. Arthur, R. W. McKenna, T. W. Le Bien, B. A. Peterson, and M. E. Nesbit, Chromosomal Abnormalities in Acute Lymphoblastic Leukemia, Cancer Res. 41: 4838 (1981).PubMedGoogle Scholar
  52. 52.
    D. C. Arthur, C. D. Bloomfield, L. L. Lindquist, and M. E. Nesbit, Jr., Translocation 4;11 in Acute Lymphoblastic Leukemia: Clinical Characteristics and Prognostic Significance, Blood 59: 96 (1982).PubMedGoogle Scholar
  53. 53.
    J. L. Parkin, D. C. Arthur, C. S. Abramson, R. W. McKenna, J. H. Kersey, R. L. Heideman, and R. D. Brunning, Acute Leukemia Associated with the t(4;11) Chromosome Rearrangement: Ultrastructural and Immunologic Characteristics, Blood 60: 1321 (1982).PubMedGoogle Scholar
  54. 54.
    M. Nagasaka, S. Maeda, H. Maeda, H.-L. Chen, K. Kita, D. Mabuchi, H. Misu, T. Matsuo, and T. Sugiyama, Four Cases of t(4;11) Acute Leukemia and its Myelomonocytic Nature in Infants, Blood 61: 1174 (1983).PubMedGoogle Scholar
  55. 55.
    R. C. Strong, S. J. Korsmeyer, J. L. Parkin, D. C. Arthur, and J. H. Kersey, Human Acute Leukemia Cell Line with the t(4;11) Chromosomal Rearrangement Exhibits B-lineage and Monocytic Characteristics, Blood 65: 21 (1985).Google Scholar
  56. 56.
    W. M. Crist, M. L. Cleary, C. E. Grossi, E. F. Prasthofer, G. D. Heggie, G. A. Omura, A. J. Carroll, M. P. Link, and J. Sklar. Acute Leukemias Associated with the 4;11 Chromosome Translocation have Rearranged Immunoglobulin Heavy Chain Genes, Blood 66: 33 (1985).PubMedGoogle Scholar
  57. 57.
    R. Abe and A. A. Sandberg, Significance of Abnormalities Involving Chromosomal Segment 11q22–25 in Acute Leukemia, Cancer Genet. Cytogenet. 13: 121 (1984).PubMedCrossRefGoogle Scholar
  58. 58.
    C. de Taisne, A. Gegonne, and D. Stehelin, Chromosomal Localization of the Human Proto-oncogene c-ets, Nature 310: 581 (1984).PubMedCrossRefGoogle Scholar
  59. 59.
    D. L. Williams, A. Tsiatis, G. M. Brodeur, A. T. Look, S. L. Melvin, W. P. Bowman, D. K. Kalwinsky, G. Rivera, and G. V. Dahl, Prognostic Importance of Chromosome Number in 136 Untreated Children with Acute Lymphoblastic Leukemia, Blood 60: 864 (1982).PubMedGoogle Scholar
  60. 60.
    A. T. Look, P. K. Roberson, D. L. Williams, G. Rivera, W. P. Bowman, C.-H. Fui, J. Ochs, M. Abromowitch, D. Kalwinsky, G. V. Dahl, S. George, and S. B. Murphy, Prognostic Importance of Blast Cell DNA Content in Childhood Acute Lymphoblastic Leukemia, Blood 65: 1079 (1985).PubMedGoogle Scholar
  61. 61.
    D. L. Williams, J. Barber, S. B. Murphy, A. T. Look, D. K. Kalwinsky, G. Rivera, S. L. Melvin, S. Strass, and G. V. Dahl, Chromosomal Translocations Play a Unique Role in Influencing Prognosis in Childhood Acute Lymphoblastic Leukemia, Blood, in press (1986).Google Scholar
  62. 62.
    J. H. Goldie and A. J. Coldman, The Genetic Origin of Drug Resistance in Neoplasms: Implications for Systemic Therapy, Cancer Res. 44: 3643 (1984).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • A. Thomas Look
    • 1
  • Dorothy L. Williams
    • 1
  • Joseph V. Simone
    • 1
  1. 1.St. Jude Children’s Research HospitalMemphisUSA

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