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Dietary Protein and Cancer

  • Willard J. Visek
  • Stephen K. Clinton
Chapter
Part of the Human Nutrition book series (HUNU, volume 7)

Abstract

The average life expectancy for Americans has increased by almost 25 years since 1900. Eighty-five years ago infectious diseases were the leading cause of death. In the growing population of industrial workers of that time, accidents were also a major cause of morbidity and shortened lifespan. The significant gains in life expectancy have been largely due to improved preventive measures facilitated by advances in sanitation, nutrition, and industrial health. Prolongation of survival has produced a population of aged people with high rates of cardiovascular disease and cancer. Together, these diseases currently account for approximately 70% of deaths in the United States. Consequently, a major fraction of our health care expenditures and allocations of funds for biomedical research has been directed to the treatment of these diseases. Despite these efforts, overall age-adjusted mortality from cancer has remained remarkably constant, although there have been dramatic reductions in mortality from some of the rarer forms of neoplasia, like Hodgkin’s disease, childhood leukemia, and testicular cancer. The slow progress in the therapy of major cancers, as perceived by the public and lawmakers, has stimulated a resurgence of interest in cancer causation and prevention.

Keywords

Protein Intake Dietary Protein Colon Carcinogenesis Mammary Carcinogenesis Syrian Golden Hamster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albanes, D., 1987, Total calories, body weight, and tumor incidence in mice, Cancer Res. 47: 1987–1992.Google Scholar
  2. American Institute of Nutrition, 1977, Report of the AIN Ad Hoc Committee on Standards for Nutritional Studies, J. Nutr. 107: 1340–1348.Google Scholar
  3. American Institute of Nutrition, 1980, Second Report of the Ad Hoc Committee on Standards for Nutritional Studies, J. Nutr. 110: 1726.Google Scholar
  4. Anderson, P. A., Alster, J. M., Clinton, S. K., Imrey, P. B., Mangian, H. J., Truex, C. R., and Visek, W. J., 1985, Plasma amino acids and excretion of protein end products by mice fed 10% or 40% soybean protein diets with or without dietary benzo(a)pyrene or 1,2-dimethylhydrazine, J. Nutr. 115: 1515.Google Scholar
  5. Anthony, P. D., 1977, Cancer of the liver: Pathogenesis and recent aetiological factors, Trans. R. Soc. Trop. Med. Hyg. 71: 466–470.Google Scholar
  6. Appleton, B. S., and Campbell, T. C., 1983a, Effect of high and low dietary protein on the dosing periods of aflatoxin BI-induced hepatic preneoplastic lesion development in the rat, Cancer Res. 43: 2150–2154.Google Scholar
  7. Appleton, B. S., and Campbell, T. C., 1983b, Dietary protein intervention during the postdosing phase of aflatoxin B1-induced hepatic preneoplastic lesion development, J. Natl. Cancer Inst. 70: 547–549.Google Scholar
  8. Armstrong, B., and Doll, R., 1975, Environmental factors and cancer incidence and mortality in different countries with special reference to dietary practices, Int. J. Cancer 15: 617–631.Google Scholar
  9. Armstrong, B., Garrod, A., and Doll, R., 1976, A retrospective study of renal cancer with special reference to coffee and animal protein consumption, Br. J. Cancer 33: 127–136.Google Scholar
  10. Berg, J. W., and Howell, M. A., 1974, The geographic pathology of bowel cancer, Cancer 34: 805–814.Google Scholar
  11. Bingham, S., Williams, D. R. R., Cole, T. J., and James, W. P. T., 1979, Dietary fibre and regional large-bowel cancer mortality in Britain. Br. J. Cancer 40: 456–463.Google Scholar
  12. Birt, D., Salmasi, S., and Pour, P., 1981, Enhancement of experimental pancreatic cancer in Syrian golden hamsters by dietary fat, J. Natl. Cancer Inst. 67: 1327–1332.Google Scholar
  13. Birt, D., Stepan, K., and Pour, P., 1983, Interaction of dietary fat and protein on pancreatic carcinogenesis in Syrian golden hamsters, J. Natl. Cancer Inst. 71: 355–360.Google Scholar
  14. Birt, D., Julius, A., Hagesawa, R., St. John, M., and Cohen, S., 1987, Effect of L-tryptophan excess and vitamin B6 deficiency on rat urinary bladder cancer promotion, Cancer Res. 47: 1244–1250.Google Scholar
  15. Bjelke, E., 1978, Dietary factors and the epidemiology of cancer of the stomach and large bowel. Aktuel. Ernaehrungsmed. Klin. Prax. Suppl. 2: 10–17.Google Scholar
  16. Buell, P., 1973, Changing incidence of breast cancer in Japanese — American women, J. Natl. Cancer Inst. 51: 1479–1483.Google Scholar
  17. Burns, R. A., and Milner, J. A., 1984, Effect of arginine on the carcinogenicity of 7,12-dimethylbenz(a)anthracene and N-methyl-N-nitrosourea, Carcinogenesis 5: 1539–1542.Google Scholar
  18. Carroll, K. K., 1975, Experimental evidence of dietary factors and hormone-dependent cancers, Cancer Res. 35: 3374–3383, 1975.Google Scholar
  19. Carroll, K. K., and Khor, K. T., 1975, Dietary fat in relation to tumorigenesis, Prog. Biochem. Pharm. 10: 308–353.Google Scholar
  20. Clinton, S. K., and Visek, W. J., 1986, The macronutrients in experimental carcinogenesis of the breast, colon, and pancreas, In: Dietary Fat and Cancer, Volume 222 ( A. Rogers, D. Birt, and C. Ip, eds.), Prog. Clin. Biol. Res., Alan R. Liss, New York, pp. 377–401.Google Scholar
  21. Clinton, S. K., Destree, R. J., Anderson, D. B., Truex, C. R., Imrey, P. B., and Visek, W. J., 1979a, Dimethylhydrazine-induced intestinal cancer in rats fed beef or soybean protein, Nutr. Rep. Int. 20: 335.Google Scholar
  22. Clinton, S. K., Truex, C. R., and Visek, W. J., 19796, Dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats, J. Nutr. 109: 55–62.Google Scholar
  23. Clinton, S. K., Truex, C. R., Imrey, P. B., and Visek, W. J., 1980, Dietary protein and mixed function oxidase activity, In: Microsomes, Drug Oxidations, and Carcinogenesis ( M. J. Coon, ed.), Academic Press, New York, pp. 1129–1132.Google Scholar
  24. Clinton, S. K., Imrey, P. B., Alster, J. M., Simon, J., Truex, C. R., and Visek, W. J., 1984, The combined effects of dietary protein and fat on 7, l2-dimethylbenz(a)anthracene-induced breast cancer in rats, J. Nutr. 114: 1213–1223.Google Scholar
  25. Clinton, S. K., Li, S., and Visek, W. J., 1985, The combined effects of dietary protein and fat on prolactin in female rats, J. Nutr. 115: 311–318.Google Scholar
  26. Clinton, S. K., Alster, J. M., Imrey, P. B., Nandkumar, S., Truex, C. R., and Visek, W. J., 1986, Effects of dietary protein, fat and energy intake during an initiation phase study of 7,12-dimethylbenz(a)anthraceneinduced breast cancer in rats, J. Nutr. 116: 2290–2302.Google Scholar
  27. Clinton, S. K., Dieterich, M., Bostwick, D. G., Olson, L. M., Montag, A. G., Michelassi, F., and Visek, W. J., 1987, The effects of ammonia on N-methyl-N’-nitrosoguanidine (MNNG)-induced colon carcinogenesis and RAS oncogene (p21) expression, Fed. Proc. 46: 585.Google Scholar
  28. Clinton, S. K., Bostwick, D. G., Olson, L. M., Mangian, H. J., and Visek, W. J., 1988a, Ammonia and cholic acid as promoters of N-methyl-N’-nitrosoquanidine (MNNG)-induced colon carcinogenesis in rats, Cancer Res. 48: 3035–3039.Google Scholar
  29. Clinton, S. K., Imrey, P. B., Alster, J. M., Simon, J., and Visek, W. J., 1988b, The combined effects of dietary protein and fat intake during the promotion phase of 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats, J. Nutr. 118: 1577–1585.Google Scholar
  30. Cohen, L. A., 1986, Dietary fat and mammary cancer, In: Diet, Nutrition, and Cancer: A Critical Evaluation ( B. S. Reddy, L. A. Cohen, eds.), CRC Press, Boca Raton, FL, Chapter 6.Google Scholar
  31. Cohen, S. M., Arai, M., Jacobs, J. B., and Friedell, G. H., 1979, Promoting effect of saccharin and DI,tryptophane in urinary bladder carcinogenesis, Cancer Res. 39: 1207–1217.Google Scholar
  32. Demopoulos, H. B., 1966, Effects of reducing the phenylalanine-tyrosine intake of patients with advanced malignant melanoma, Cancer 19: 657–664.Google Scholar
  33. Doll, R., 1978, Geographic variation in cancer incidence: A clue to causation, World J. Surg. 2: 595–602.Google Scholar
  34. Doll, R., and Peto, R., 1981, The Causes of Cancer, Oxford University Press, New York.Google Scholar
  35. Dunning, W. F. Curtis, M. R., and Mann, M. E., 1950, The effect of added dietary tryptophan on the occurrence of 2-acetylaminofluorene-induced liver and bladder cancer, Cancer Res. 10: 454–459.Google Scholar
  36. Elliott, T. S., Robinson, J. L., and Visek, W. J., 1987, Influence of dietary orotic acid on hepatocarcinogenesis in Fischer-344 and Sprague-Dawley rats, Fed. Proc. 46: 746.Google Scholar
  37. Enstrom, J. E., 1975, Colorectal cancer and consumption of beef and fat, Br. J. Cancer 32: 432–439.Google Scholar
  38. Ernster, V. L., Selvin, S., Sacks, S. T., Austin, D. F., Brown, S. M., and Winklestein, W., Jr., 1978, Prostatic cancer: Mortality and incidence rates by race and social class, Am. J. Epidemiol. 107 (4): 311–320.Google Scholar
  39. Gaskill, S. P., McGuire, W. L., Osborne, C. K., and Stern, M. P., 1979, Breast cancer mortality and diet in the United States, Cancer Res. 39: 3628.Google Scholar
  40. Graham, S., Levin, M., and Lilienfeld, A. M., 1960, The socioeconomic distribution of cancer of various sites in Buffalo, NY, 1948–1952, Cancer 13: 180–191.Google Scholar
  41. Graham, S., Dayal, H., Swanson, M., Mittelman, A., and Wilkinson, G., 1978, Diet in the epidemiology of cancer of the colon and rectum, J. Nail. Cancer Inst. 61: 709–714.Google Scholar
  42. Gray, G. E., Pike, M. C., and Henderson, B. E., 1979, Breast-cancer incidence and mortality rates in different countries in relation to known risk factors and dietary practices, Br. J. Cancer 39: 1.Google Scholar
  43. Greenwald, P., Kirmas, V., Polan, A. K., and Dick, V. S., 1974, Cancer of the prostate among men with benign prostatic hyperplasia, J. Natl. Cancer Inst. 53: 335–340.Google Scholar
  44. Gregor, O., Toman, R., and Prusova, F., 1969, Gastrointestinal cancer and nutrition, Gut 10: 1031–1034.Google Scholar
  45. Gregor, O., Toman, R., and Prusove, F., 1971, Relation of gastrointestinal cancer mortality to cancer mortality in general, Scand. J. Gastroenterol. 9: 79–85.Google Scholar
  46. Haenszel, W., and Kurihara, M., 1968, Studies of Japanese migrants. I. Mortality from cancer and other disease among Japanese in the United States, J. Natl. Cancer Inst. 40: 43–68.Google Scholar
  47. Haenszel, W., Berg, J. W., Segi, M., Kurihara, M., and Locke, F. B., 1973, Large-bowel cancer in Hawaiian Japanese J. Natl. Cancer Inst. 51: 1765–1779.Google Scholar
  48. Haenszel, W., Locke, F. B., and Segi, M., 1980, A case-control study of large bowel cancer in Japan, J. Natl. Cancer Inst. 64: 17–22.Google Scholar
  49. Hawrylewicz, E. J., 1986, Fat-protein interaction, defined 2-generation studies, In: Dietary Fat and Cancer ( C. Ip, D. Birt, A. Rogers, and C. Mettlin, eds.), Alan R. Liss, New York, pp. 403–433.Google Scholar
  50. Hawrylewicz, E. J., Huang, H. H., Kissane, J. Q., and Drab, E., 1982, Enhancement of 7,12-dimethylbenz(a)anthracene (DMBA) mammary tumorigenesis by high dietary protein in rats, Nutr. Rept. Int. 26: 793–806.Google Scholar
  51. Hems, G., 1978, The contributions of diet and childbearing to breast-cancer rates, Br. J. Cancer 37: 974.Google Scholar
  52. Hems, G. 1980, Associations between breast-cancer mortality rates, child-bearing and diet in the United Kingdom, Br. J. Cancer 41: 429.Google Scholar
  53. Hevia, P., Truex, C. R., Imrey, P. B., Clinton, S. K., Mangian, H. J., and Visek, W. J., 1984, Plasma amino acids and excretion of protein end products by mice fed 10% or 40% soybean protein diets with or without dietary 2-acetyl-aminofluorene orN-N-dinitrosopiperazine, J. Nutr. 114: 555–564.Google Scholar
  54. Higginson, J., and Oettle, A. G., 1960, Cancer incidence in the Banta and “Cape Colored” races of South Africa: Report of a cancer survey in the Transvaal (1935–1955), J. Natl. Cancer Inst. 24: 589–671.Google Scholar
  55. Hill, A. B., 1965, The environment and disease: Association and causation, Proc. R. Soc. Med. 58: 295–300.Google Scholar
  56. Hill, P., Wynder, E. L., Garbaczewski, L., Giarnes, H., and Walker, A. R. P., 1979, Diet and urinary steroids in black and white North American men and black South African men, Cancer Res. 39: 5101–5105.Google Scholar
  57. Hill, P., Garbaczewski, L., Helman, P., Walker, A. R. P., Gurnes, H., and Wynder, E. L., 1981, Environmental factors and breast prostate cancer, Cancer Res. 41: 3817–3818.Google Scholar
  58. Hill, P., Wynder, E. L., Garbaczewski, L., Games, H., and Walker, A. R., 1982, Response to leutinizing releasing hormone, thyrotropic releasing hormine, and human chronic genadotropin administration in healthy men at different risks for prostate cancer and in prostate cancer patients, Cancer Res. 42: 2074–2080.Google Scholar
  59. Hirayama, T., 1977, Changing patterns of cancer in Japan with special reference to the decrease in stomach cancer mortality, In: Origins of Human Cancer, Book A: Incidence of Cancer in Humans ( H. H. Hiatt, J. D. Watson, and J. A. Winsten, eds.), Cold Spring Harbor Laboratory, New York, pp. 55–75.Google Scholar
  60. Hirayama, T., 1981, A large-scale cohort study on the relationship between diet and selected cancers of the digestive organs, In: Gastrointestinal Cancer, Endogenous Factors; Banbury Report 7 ( W. R. Bruce, P. Correa, M. Lipkin, S. R. Tannenbaum, and T. D. Wilkins, eds.), Cold Spring Harbor Laboratory, New York, pp. 409–429.Google Scholar
  61. Howell, M. A., 1975, Diet as an etiological factor in the development of cancers of the colon and rectum, J. Chronic Dis. 28: 67–80.Google Scholar
  62. Huang, H. H., Hawrylewicz, E. J., Kissane, J. Q., and Drab, E. A., 1982, Effect of protein diet on release of prolactin and ovarian steroids in female rats, Nutr. Rep. Int. 26: 807–820.Google Scholar
  63. Hutchinson, G. B., 1976, Epidemiology of prostate cancer, Semin. Oncol. 3: 151–159.Google Scholar
  64. Ishii, K., Nakamura, K., Ozaki, H., Yamada, N., and Takeuchi, T., 1968, [Epidemiological problems of pancreas cancer], Jpn. J. Clin. Med. 26: 1839–1842.Google Scholar
  65. Jain, M., Cook, G. M., Davis, F. G., Grace, M. G., Howe, G. R., and Miller, A. B., 1980, A case—control study of diet and colorectal cancer, Int. J. Cancer 26: 757–768.Google Scholar
  66. Jensen, O. M., 1986, The epidemiology of large bowel cancer, In: Diet, Nutrition and Cancer: A Critical Evaluation ( B. S. Reddy and L. A. Cohen, eds.) CRC Press, Baca Raton, FL, Chapter 3.Google Scholar
  67. Jose, D., 1979, Dietary deficiency of protein, amino acids and total calories on development and growth of cancer, Nutr. Cancer 1: 58–63.Google Scholar
  68. Kappas, A., Anderson, K. E., Conney, H. H., and Alvares, A. P., 1976, Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man, Clin. Pharmacol. Ther. 20: 643–653.Google Scholar
  69. Kari, F. W., Johnston, J. B., Truex, C. R., and Visek, W. J., 1983, Effect of dietary protein concentration on yield of mutagenic metabolites from 1,2-dimethylhydrazine in mice, Cancer Res. 43 (8): 3674–3679.Google Scholar
  70. Kelsey, J. L., 1979, A review of the epidemiology of human breast cancer, Epidemiol. Rev. 1: 74–109.Google Scholar
  71. King, H., Diamond, E., and Lilienfeld, A. M., 1963, Some epidemiological aspects of cancer of the prostate, J. Chronic Dis. 16: 117–153.Google Scholar
  72. Knox, E. G., 1977, Foods and diseases, Br. J. Prey. Soc. Med. 37: 71–80.Google Scholar
  73. Kolonel, L. N., Hankin, J. H., Lee, J., Chu, S. Y., Nomura, A. M., and Hinds, M. W., 1981, Nutrient intakes in relation to cancer incidence in Hawaii, Br. J. Cancer 44 (3): 332–339.Google Scholar
  74. Kolonel, L. N., Nomura, A. M., Hinds, M. W., Hirohata, T., Hankin, J. H., and Lee, J., 1983, Role of diet in cancer incidence in Hawaii, Cancer Res. 43: 2397–2402.Google Scholar
  75. Krain, L. S., 1974, Some epidemiologic variables in prostatic carcinoma in California, Prey. Med. 3: 154–159.Google Scholar
  76. Laurier, C., Tatematsu, M., Rao, P. M., Rajalaksami, S., and Sarnia, D. S. R., 1984, Promotion by orotic acid of liver carcinogenesis in rats initiated by 1,2-dimethylhydrazine, Cancer Res. 44: 2186–2191.Google Scholar
  77. Lea, A. J., 1967, Neoplasms and environmental factors, Ann. R. Coll. Surgeons Engl. 41: 432.Google Scholar
  78. Lennard-Jones, J. E., Morson, B. C., Ritchie, J. K., Shove, D. C., and Williams, C. B., 1977, Cancer in colitis: Assessment of individual risk by clinical and histological criteria, Gastroentrology 73: 1280–1289.Google Scholar
  79. Lijinsky, W., and Shubik, P., 1964, Benzo(a)pyrene and other polynuclear aromatic hydrocarbons in charcoal broiled meat, Science 145: 53–55.Google Scholar
  80. Lin, H. C., and Visek, W. J., 1988, Effect of dietary protein and fat on fecal ammonia and intracolonic pH in male Holtzman rats, J. FASEB 2: A857 (abstr.).Google Scholar
  81. Longnecker, D., Roebuck, B., Yager, J., Lilja, H., and Siegmund, B., 1981, Pancreatic carcinoma in azaserinetreated rats: Induction, classification, and dietary modulation of incidence, Cancer 47: 1562–1572.Google Scholar
  82. Lorincz, A. B., and Kuttner, R. E., 1965, Response of malignancy to phenylalanine restriction; a preliminary report on a new concept of managing malignant disease, Neb. State Med. J. 50: 609–617.Google Scholar
  83. Lubin, J. H., Burns, P. E., Blot, W. J., Ziegler, R. G., Lees, A. W., and Fraumeni, J. F., 1981, Dietary factors and breast cancer risk. Int. J. Cancer 28: 865–869.Google Scholar
  84. MacMahon, B., 1982, Risk factors and cancer of the pancreas, Cancer 50: 2676–2680.Google Scholar
  85. Madhavan, T. V., and Gopalan, C., 1965, Effect of dietary protein on aflatoxin liver injury in weanling rats, Arch. Pathol. 80: 123–126.Google Scholar
  86. Madhavan, T. V., and Gopalan, C., 1968, The effect of dietary protein on carcinogenesis of aflatoxin, Arch. Pathol. 85: 133–137.Google Scholar
  87. McLean, A. E., and Magee, P. N., 1970, Increased renal carcinogenesis by dimethylnitrosamine in protein deficient rats, Br. J. Exp. Pathol. 51: 587–590.Google Scholar
  88. Meyer, F., 1977, Relationship between diet and carcinoma of the stomach, colon, rectum, and pancreas in France. Gastroenterol. Clin. Biol. 1: 971–982.Google Scholar
  89. Miller, A. B., Kelly, A., Choi, N. W., Matthews, V., Morgan, R. W., Munan, L., Burch, J. D., Feather, J., Howe, G. R., and Jain, M., 1978, A study of diet and breast cancer, Am. J. Epidemiol. 107 (6): 499–509.Google Scholar
  90. Miyakawa, M., and Yoshida, O., 1973, DNA synthesis of the urinary bladder epithelium in rats with long term feeding of DL-tryptophane-added and pyridoxine-deficient diet, Gann 64: 411–413.Google Scholar
  91. Moreschi, C., Beziehungen Zwischen Ernahrung und Tumorwachstein, Zlmmunitatsforsch 2: 651–685, 1909.Google Scholar
  92. Muto, T., Bussey, H. J. R., and Morson, B. C., 1975, The evolution of cancer of the colon and rectum, Cancer 36: 2251–2270.Google Scholar
  93. National Academy of Sciences, 1982, Committee on Diet, Nutrition, and Cancer, National Research Council, Diet, Nutrition, and Cancer, National Academy Press, Washington, DC.Google Scholar
  94. National Research Council, 1978, Nutrient Requirements of Laboratory Animals, No. 10, 3rd rev. ed., National Academy of Sciences, Washington, DC.Google Scholar
  95. Newbeme, P., Bieri, J., Briggs, G., and Nesheim, M., 1978, Control of diets in laboratory animal experimentation. Inst. Lab. Animals Res. New 21: A1 - A2.Google Scholar
  96. O’Brian, J. G., Simsiman, R. C., and Boutwell, R. K., 1975, Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor promoting agents, Cancer Res. 35:1662–1670.Google Scholar
  97. Phillips, R. L., 1975, Role of life-style and dietary habits in risk of cancer among Seventh-Day Adventists, Cancer Res. 35: 3513–3522.Google Scholar
  98. Phillips, R. L., and Snowdon, D. A., 1985, Dietary relationships with fatal colorectal cancer among Seventh-Day Adventists, J. Natl. Cancer Inst. 74: 307–317.Google Scholar
  99. Pour, P., and Birt, D., 1983, Modifying factors in pancreatic carcinogenesis in the hamster model. IV. Effects of dietary protein, J. Natl. Cancer Inst. 71: 347–353.Google Scholar
  100. Pour, P., Birt, D., Salmasi, S., and Gotz, U., 1983, Modifying factors in pancreatic carcinogenesis in the hamster model. I. The effect of protein-free diet fed during early stages of carcinogenesis, J. Natl. Cancer Inst. 70: 141–146.Google Scholar
  101. Preston, R. S., Hayes, J. R., and Campbell, T. C, 1976, The effect of protein deficiency on the in vivo binding of aflatoxin Bt to rat liver macromolecules, Life Sci. 19: 1191–1197.Google Scholar
  102. Radmoski, J. L., Glass, E. M., and Deichmann, W. B., 1971, Transitional cell hyperplasia in the bladders of dogs fed DL-tryptophan, Cancer Res. 31: 1690–1694.Google Scholar
  103. Rao, P. M., Agamine, Y. N., Roomi, M. W., Rajalakshmi, S., and Sarma, D. S. R., 1984, Orotic acid, a new promoter for experimental liver carcinogenesis, Toxicol. Pathol. 12: 173–178.Google Scholar
  104. Rao, P. M., Rajalakshimi, S., Alam, A., Sarma, D. S. R., Pala, M., and Parodi, S., 1985, Orotic acid, a promoter of liver carcinogenesis, induces DNA damage in rat liver, Carcinogenesis 6: 765–768.Google Scholar
  105. Reddy, B. S., 1983, Experimental research on dietary lipids and colon cancer, In: Dietary Fats and Health ( E. G. Perkins and W. J. Visek, eds.), Am. Oil Chemists’ Society, Champaign, IL, pp. 741–760.Google Scholar
  106. Reddy, B. S., 1986, Diet and colon cancer: Evidence from human and animal model studies, In: Diet, Nutrition, and Cancer: A Critical Evaluation, Volume 1 ( B. S. Reddy and L. A. Cohen, eds.), CRC Press, Boca Raton, FL, pp. 46–65.Google Scholar
  107. Richardson, I. M., 1965, Prostate cancer and social class, Br. J. Prey. Soc. Med. 19: 140–142.Google Scholar
  108. Roebuck, B., Yager, J., and Longnecker, D., 1981, Dietary modulation of azaserine-induced pancreatic carcinogenesis in rats. Cancer Res. 41: 888–893.Google Scholar
  109. Roebuck, B., Longnecker, D., Baumgartner, K., and Thron, C., 1985, Carcinogen-induced lesions in the rat pancreas: Effects of varying levels of essential fatty acid, Cancer Res. 45: 5252–5256.Google Scholar
  110. Roebuck, B. D., Kaplita, P. V., Edwards, B. R., and Praissman, M., 1987, Effects of dietary fats and soybean protein on azaserine-induced pancreatic carcinogenesis and plasma cholecystokinin in the rat, Cancer Res. 47: 1333–1338.Google Scholar
  111. Ross, M. H., and Bras, G., 1973, Influence of protein under-and ovemutrition on spontaneous tumor prevalence in the rat, J. Nutr. 103: 944–1963.Google Scholar
  112. Ross, M. H., Bras, G., and Raybeer, M. S., 1970, Influence of protein and caloric intake upon spontaneous tumor incidence of the anterior pituitary gland of the rat, J. Nutr. 100: 177–189.Google Scholar
  113. Ross, R. K., Shimizu, H., Paganini-Hill, A., Henda, G., and Henderson, B., 1987, Case-control studies of prostate cancer in blacks and whites in Southern California, J. Natl. Cancer Inst. 78: 869–874.Google Scholar
  114. Rotkin, I. D., 1977, Studies in the epidemiology of prostatic cancer; expanded sampling, Cancer Treat Rep. 61: 173–180.Google Scholar
  115. Rous, P., 1914, The influence of diet on transplanted and spontaneous mouse tumours, J. Expl. Med. 20: 433–451.Google Scholar
  116. Russell, D. H., and Snyder, S. H., 1968, Amine synthesis in rapidly growing tissue: Ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors, Proc. Natl. Acad. Sci. USA 60: 1420–1427.Google Scholar
  117. Sakata, T., Shirai, T., Fukushima, S., Hasegawa, R., and Ito, N., 1984, Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxy-butyl)nitrosamine in F344 rats, Gann 74: 950–956.Google Scholar
  118. Sandford, E. J., Geder, L., Laychock, A., Rohner, J., and Rapp, F., 1977, Evidence for the association of cytomegalovirus with carcinoma of the prostate, J. Urol. 118: 789–792.Google Scholar
  119. Shay, H., Gruenstein, M., and Shimkin, M. B., 1964, Effect of casein, lactalbumin, and ovalbumin on 3-methylcholanthrene-induced mammary carcinoma in rats, J. Natl. Cancer Inst. 33: 243.Google Scholar
  120. Siegler, J. M., and Kazarinoff, M. N., 1983, Effects of acute and chronic protein deprivation on ornithine decarboxylase levels in rat liver and colon, Nutr. Cancer 4: 176–185.Google Scholar
  121. Siegler, J. M., and Kazarinoff, M. N., 1984, The effect of a low protein diet on the response of rat colonic and hepatic ornithine decarboxylase activity to sodium deoxycholate and thioacetamide treatment, J. Nutr. 114: 574–580.Google Scholar
  122. Silverberg, E., and Lubera, J., 1987, Cancer statistics, Ca-A Cancer Journal for Clinicians, 37: 2–19.Google Scholar
  123. Silverstone, H., 1948, The levels of carcinogenic azo dyes in the livers of rats fed various diets containing p-dimethylamino-azobenzene: Relationship to the formation of hepatomas, Cancer Res. 8: 301–308.Google Scholar
  124. Silverstone, H., and Tannenbaum, A., 1951, Proportion of dietary protein and the formation of spontaneous hepatomas in the mouse, Cancer Res. 11: 442–446.Google Scholar
  125. Singletary, K. W., and Milner, J. A., 1987a, Influence of prior dietary protein intake on metabolism, DNA binding and adduct formation of 7,12-dimethylbenz(a)anthracene in isolated rat mammary epithelial cells, J. Nutr. 117: 587–592.Google Scholar
  126. Singletary, K. W., and Milner, J. A., 19876, Prior dietary protein intake and DNA-binding 7,12-dimethylbenz(a)anthracene metabolites formed by isolated rat hepatocytes, J. Natl. Cancer Inst. 78: 727–733.Google Scholar
  127. Singletary, K. W., Milner, J. A., and Martin, S. E., 1984, Effect of dietary protein concentration on rat-liver S-9 pioactivation of 7,12-dimethylbenz(a)anthracene in the salmonella/microsome assay, Mutation Res. 126: 19–24.Google Scholar
  128. Staszewski, J., and Haenszel, W., 1965, Cancer mortality among Polish-born in the United States, J. Natl. Cancer Inst. 35: 291–297.Google Scholar
  129. Steel, R., Lees, R. E. M., Kraus, A. S., and Rao, C., 1971, Sexual factors in the epidemiology of cancer of the prostate, J. Chronic Dis. 24: 29–37.Google Scholar
  130. Swann, P. R., and McLean, A. E., 1971, Cellular injury and carcinogenesis: The effect of a protein-free highcarbohydrate diet on the metabolism of dimethylnitrosamine in the rat, Biochem. J. 124: 283–288.Google Scholar
  131. Tabor, C. W., and Tabor, H., 1976, I,4-Diaminobutane (putrescine), spermidine, and spermine, Annu. Rev. Biochem. 45: 285–306.Google Scholar
  132. Takeda, Y., Tominaga, T., Tei, N., Kitamura, M., Taga, S., Murase, J., Taguchi, T., and Miwatani, T., 1975, Inhibitory effect of L-arginine on growth of rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene, Cancer Res. 35: 2390–2393.Google Scholar
  133. Tannenbaum, A., 1959, Nutrition and cancer, In: The Pathophysiology of Cancer (F. Homburger, cd.), Hober and Harper, New York, pp. 517–562.Google Scholar
  134. Tannenbaum, A., and Silverstone, H., 1949, The genesis and growth of tumors. IV. Effects of varying the proportion of protein (casein) in the diet, Cancer Res. 9: 162–173.Google Scholar
  135. Temcharoen, P., Anukarahanonta, T., and Bhamarapravati, N., 1978, Influence of dietary protein and vitamin B12 on the toxicity and carcinogenicity of aflatoxins in rat liver, Cancer Res. 38: 2185–2190.Google Scholar
  136. Topping, D. C., and Visek, W. J., 1976, Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine, J. Nutr. 106: 1583–1590.Google Scholar
  137. Visek, W. J., 1972, Effects of urea hydrolysis on cell life-span and metabolism, Fed. Proc. 31: 1178–1193.Google Scholar
  138. Visek, W. J., 1978, Diet and cell growth modulation by ammonia. Am. J. Clin. Nutr. 31: 5216–5220.Google Scholar
  139. Visek, W. J., Mangian, H., Elliott, T. S., Ruskin, B., Bragg, D. S. A., and Robinson, J. L., 1988, Renal damage and urinary lithiasis in mice fed orotic acid (OA), J. FASEB 2: A863 (abstr.).Google Scholar
  140. Walters, M. A., and Roe, F. J. C., 1964, The effect of dietary casein on the induction of lung tumours by the injection of 9,10-dimethyl-1,2-benzanthracene (DMBA) into newborn mice, Br. J. Cancer 18: 312–316.Google Scholar
  141. Watt, B. K., and Merrill, A. L., 1975, Composition of Foods, Agriculture Handbook, No. 8, USDA, Washington, DC.Google Scholar
  142. Wattenberg, L. W., 1975, Effects of dietary constituents on the metabolism of chemical carcinogens, Cancer Res. 35: 3526–3531.Google Scholar
  143. Wells, P., Alftergood, L., and Alfin-Slater, R. B., 1976, Effect of varying levels of dietary protein on tumor development and lipid metabolism in rats exposed to aflatoxin, J. Am. Oil Chem. Soc. 53: 559–562.Google Scholar
  144. Welsch, C. W., 1986, Interrelationship between dietary fat and endocrine processes in mammary gland tumorigenesis, In: Dietary Fat and Cancer (C. Ip, D. Birt, A. Rogers, and C. Mettlin, eds.), Prog. Clin. Biol. Res., Volume 222, Alan R. Liss, New York, pp. 623–654.Google Scholar
  145. Woolf, C. M., 1960, An investigation of the familial aspects of carcinoma of the prostate, Cancer 13: 739–744.Google Scholar
  146. Woteke, C. E., Briefel, R. R., and Sempos, C., 1987, Nutritional epidemiology and national surveys, J. Nutr. 117: 401–402.Google Scholar
  147. Wynder, E. L., 1975, An epidemiological evaluation of the causes of cancer of the pancreas, Cancer Res. 35: 2228–2233.Google Scholar
  148. Wynder, E. L., Mabuchi, K., Maruchi, N., and Fortner, J. G., 1973, Epidemiology of cancer of the pancreas, J. Natl. Cancer Inst. 50: 645–667.Google Scholar
  149. Zaldivan, R., Wetterstrand, W. H., and Ghai, A. L., 1981, Relative frequency of mammary, colonic, rectal, and pancreatic cancer in a large autopsy series. Statistical Association between mortality rates from these cancers: Dietary fat intake as a common etiological variable, Zentralbi. Bakteriol. (Naturwiss.) 169: 474–481.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Willard J. Visek
    • 1
  • Stephen K. Clinton
    • 2
  1. 1.Division of Nutritional Sciences, Department of Internal MedicineCollege of Medicine, University of IllinoisUrbanaUSA
  2. 2.The Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA

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