Advertisement

Interactions of a Catalase- and an Urease-Negative Mutant of Helicobacter Pylori with Polymorphonuclear Granulocytes

  • Martin Marxer
  • Fardad Farzam
  • Christiane Spiegelhalder
  • Astrid Kersten
  • Stefan Odenbreit
  • Rainer Haas
  • Manfred Kist

Abstract

Polymorphonuclear neutrophilic granulocytes (PMNs) accumulate in large numbers in the gastric mucosa at sites of Helicobacter pylori (H. pylori) infection. The PMNs are found in close vicinity to the bacterial cells, as has been shown by histological examinations of biopsy specimens.1,5 Despite this close proximity, H. pylori is not eradicated and the infection becomes chronic. Obviously H. pylori has developed effective escape mechanisms against the enormous destructive potential of the activated PMNs and establishes a chronic infection. The lasting immune response could be one of the major reasons for the inflammation that can lead to damage of the epithelial cells, resulting in ulcers and carcinomas.

Keywords

Oxidative Burst Reactive Oxygen Metabolite Adhere Bacterium Phagocytosis Assay Free Bacterium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kist M. (1989) in: R. Ottenjann und W. Schmitt (Hrsg.), Aktuelle Gastroenterologie — Campylobacter pylori, pp. 66–74. Springer Verlag, Berlin-Heidelberg-New York.Google Scholar
  2. 2.
    Kist M., Spiegelhalder C., Moriki T. and Schaefer H.E. (1993) Zbl. Bakteriol., 280, 58–72.CrossRefGoogle Scholar
  3. 3.
    Rautelin H., von Bonsdorff C.H., Blomberg B. and Danielsson D. (1994) J. Clin. Pathol., 47, 667–669.PubMedCrossRefGoogle Scholar
  4. 4.
    Rothe G., Emmendörffer A., Oser A., Roesler J. and Valet G. (1991) J. Immunol. Meth., 138, 133–135.CrossRefGoogle Scholar
  5. 5.
    Sobala G.M., Crabtree J., Dixon M.F., Schorah C.J., Taylor D., Rathbone B.J., Heatley R.V. and Axon A.T-R. (1991) Gut, 32, 1415–1418.PubMedCrossRefGoogle Scholar
  6. 6.
    Smith J.A. and Weidemann M.J. (1993) J. Immunol. Meth., 162, 261–268.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Martin Marxer
    • 1
  • Fardad Farzam
    • 1
  • Christiane Spiegelhalder
    • 1
  • Astrid Kersten
    • 2
  • Stefan Odenbreit
    • 3
  • Rainer Haas
    • 3
  • Manfred Kist
    • 1
  1. 1.Inst. für Med. Mikrobiologie und HygieneFreiburgGermany
  2. 2.Pathologisches InstitutUniversität FreiburgFreiburgGermany
  3. 3.MPI für BiologieTübingenGermany

Personalised recommendations