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Effect on Pepsinogen Release of Various Sub-Fractions of H. Pylori Lipopolysaccharide

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Campylobacters, Helicobacters, and Related Organisms

Abstract

The association between H.pylori and duodenal ulcer (DU) disease is well recognized. The role played by H.pylori is, however, less clear. We have previously reported that H.pylori lipopolysaccharide (LPS) stimulates the release of pepsinogen which, as active pepsin, is a known aggressive factor in DU disease7. LPS is a complex molecule, consisting of carbohydrate and lipid moieties, and may also have protein associated with it4. The aim of the study was to examine the effect of sub-fractions of LPS on pepsinogen release by guinea pig gastric mucosa, in order to determine whether any particular moiety is the “active fraction”.

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References

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Author information

Authors and Affiliations

  1. Gastrointestinal Clinic, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa

    G. O. Young & S. Brown

  2. Department of Medical Microbiology, Red Cross Children’s Hospital, Cape Town, South Africa

    A. J. Lastovica

  3. Department of Microbiology, University College, Galway, Ireland

    J. J. McGovern & A. P. Moran

Authors
  1. G. O. Young
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  2. A. J. Lastovica
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  3. S. Brown
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  4. J. J. McGovern
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  5. A. P. Moran
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Editor information

Editors and Affiliations

  1. Central Veterinary Laboratory, Addlestone, UK

    Diane G. Newell

  2. University of Leicester, Leicester, UK

    Julian M. Ketley

  3. The London Hospital Medical College, London, UK

    Roger A. Feldman

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© 1996 Springer Science+Business Media New York

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Young, G.O., Lastovica, A.J., Brown, S., McGovern, J.J., Moran, A.P. (1996). Effect on Pepsinogen Release of Various Sub-Fractions of H. Pylori Lipopolysaccharide. In: Newell, D.G., Ketley, J.M., Feldman, R.A. (eds) Campylobacters, Helicobacters, and Related Organisms. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9558-5_132

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  • DOI: https://doi.org/10.1007/978-1-4757-9558-5_132

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9560-8

  • Online ISBN: 978-1-4757-9558-5

  • eBook Packages: Springer Book Archive

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