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A Binding-Lipoprotein-Dependent Transport System for a Ferric-Siderophore in Campylobacter Coli

  • P. T. Richardson
  • S. F. Park

Abstract

Iron is essential for the growth of most bacteria. To exist, either as pathogens or as commensals, Campylobacter coli and Campylobacter jejuni must be able to colonize the gastrointestinal tract and accordingly, must have mechanisms for acquiring iron in this complex nutritional milieu. A strategy for iron-sequestration employed by a number of bacterial pathogens comprises the secretion of highly specific chelators for Iron (III), termed siderophores, followed by their internalization via cognate high-affinity transport systems2. Campylobacter species do not, however, appear to produce detectable levels of siderophores1. It is likely, therefore, that these bacteria can compete in the heterogenous environment of the gastrointestinal tract by parasitizing siderophores produced by the indigenous microflora. For instance, both C. coli and C. jejuni can acquire iron from enterochelin and ferrichrome, siderophores which are produced by Escherichia coli and other enteric bacteria1,4.

Keywords

Iron Source Membrane Span Segment Potential Open Reading Frame Specific Chelator Ferric Siderophore 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • P. T. Richardson
    • 1
  • S. F. Park
    • 1
  1. 1.Institute of Food ResearchReading LaboratoryReadingUK

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