Evaluation of FlexSure™ HP

A Rapid Serological Assay for H. pylori Detection as Compared to HM-CAP™ EIA and EGD Biopsy
  • R. Shaw
  • M. Garcia
  • E. Cheng
  • P. Marchildon
  • J. Peacock

Abstract

Helicobacter pylori has been the source of intensive research over the last twelve years since its discovery by Marshall and Warren. It is now accepted as the etiologic agent in chronic superficial gastritis, duodenal ulcers, and gastric ulcers. There has also been established a risk association between H. pylori infection and the development of gastric adenocarcinoma and lymphoma.5,7,13,14,19 The World Health Organization (WHO) in late 1994 classified H. pylori as a definite Category 1 carcinogen, bringing its significance to the point of a public health issue and suggesting the need for broad environmental controls. In February 1994, the National Institutes of Health, (NIH) convened a Consensus Panel which issued statements regarding H. pylori diagnosis and treatment.13 The consensus statement indicated that H. pylori infection should be diagnosed by any of the sensitive and specific methodologies available. In addition it stated that H. pylori infected ulcer patients should be treated with specific anti-microbial therapies to cure the infection.

Keywords

Formalin Urea Lymphoma Adenocarcinoma Bismuth 

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References

  1. 1.
    Barthel J. S. and Everett E. D. (1990) Rev Infect Dis, 12, Sup 1:S107–S114.PubMedCrossRefGoogle Scholar
  2. 2.
    Chong S. K. F., Lou Q. and Fitzgerald J. F. (1994) Amer J Gastroenterol, 89(8): poster 204.Google Scholar
  3. 3.
    Evans D. J., Evans D. G., Graham D. Y. and Klein P. D. (1989) Gastroenterology, 96: 1004–1008.PubMedGoogle Scholar
  4. 4.
    Genta R. M. and Graham D. Y. (1994) Gastrointestinal Endoscopy, 40: 342–345.PubMedCrossRefGoogle Scholar
  5. 5.
    Graham D. Y. and Go M. F. (1993) Gastroenterology, 105: 279–282.PubMedGoogle Scholar
  6. 6.
    Graham D. Y., Klein P. D., Evans, D. J., Evans D. G., Alpert L. C., Opekun, A. R. and Boutton T. W. (1987) The Lancet, 1: 1174–1177.CrossRefGoogle Scholar
  7. 7.
    Hansson L. E., Engstrand L., Nyren O., Evans D. J., Lindgren A., Bergstron R., Andersson B., Athlin L., Bendtsen E. and Tracz P. (1993) Gastroenterology, 105: 1098–1103.PubMedGoogle Scholar
  8. 8.
    Loffeld R. J. L. F., Stobberingh E. and Arends J. W. (1993) Digestive Diseases, 11: 173–180.PubMedCrossRefGoogle Scholar
  9. 9.
    Loffeld R. J. L. F., Vriese W. T. J. and Stobberingh E. E. (1993) European J Gastroenterol & Hepatol, 5(5): 333–337.CrossRefGoogle Scholar
  10. 10.
    Logan R. P. H., Poison R. J., Misiewicz J. J., Rao G., Karim N. Q., Newell D., Johnson P., Wadsworth J., Walker M. M. and Baron J. H. (1991) Gut, 22(12): 1461–1464.CrossRefGoogle Scholar
  11. 11.
    Marshall B. J. (1994) The American Journal of Gastroenterology, 89(8): S116–S128.PubMedGoogle Scholar
  12. 12.
    Marshall B. J., Plankey M. W., Hoffman S. R., Boyd C. L., Dye K. R., Grierson H. F., Guerrant R. L. and McCallu, R. W. (1991) Am J Gastroenterol, 86(4)438–445.PubMedGoogle Scholar
  13. 13.
    National Institutes of Health (1994) JAMA, 272:65–69.CrossRefGoogle Scholar
  14. 14.
    Parsonnet J., Friedman G. D., Vandersteen D. P., Chang Y., Vogelman J. H., Orentreich N. and Sibley R. K. (1991) New England J Med, 325: 1127–1131.CrossRefGoogle Scholar
  15. 15.
    Quine M. A., Bell G. D., McCloy R. F., Charlton J. E., Devlin H. B. and Hopkins A. (1995) Gut, 36: 462–467.PubMedCrossRefGoogle Scholar
  16. 16.
    Sonnenberg A. and Townsend W. F. (1995) Arch Intern Med, 155: 922–928.PubMedCrossRefGoogle Scholar
  17. 17.
    Taha A. S., Reid J., Boothmann P., Gemmell C. G., Lee F. D., Sturrock R. D., and Russell R. I. (1993) Gut, 34(4):46–465.CrossRefGoogle Scholar
  18. 18.
    Talley N. J., Newell D. G., Ormand J. E., Carpenter H. A., Wilson W. R., Zinsmeister A. R., Perez-Perez G. L, and Blaser M. J. (1991) J Clin Microbiol, 29(8): 1635–1639.PubMedGoogle Scholar
  19. 19.
    Tompkins L. S. and Falkow S. (1995) Science, 267: 1621–1622.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • R. Shaw
    • 1
    • 2
    • 3
  • M. Garcia
    • 1
    • 2
    • 3
  • E. Cheng
    • 1
    • 2
    • 3
  • P. Marchildon
    • 4
  • J. Peacock
    • 4
  1. 1.Northport Veterans Affairs Medical CenterNorthportUSA
  2. 2.Department of MedicineState University of New York at Stony BrookStony BrookUSA
  3. 3.Research ServiceNorthport Veteran’s Administration Medical Center (632)NorthportUSA
  4. 4.Enteric Products, Inc.Stony BrookUSA

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