Cloning the Flagellin Genes of Campylobacter Upsaliensis

  • J. M. Cox
  • J. M. Ketley
  • P. H. Williams


Campylobacter upsaliensis is fast becoming recognised as a significant human pathogen, causing, amongst other symptoms, diarrhoea, bacteraemia and respiratory problems. The organism was first described by Sandstedt et al. 8 from dogs with or without diarrhoea and later from asymptomatic cats by Fox et al. 1. In subsequent studies, C. upsaliensis was isolated from human faecal samples3,6,9,11,12, human blood5,7,11, a breast abscess2 and foetoplacental tissues4. However, relatively little is known about the virulence determinants of C. upsaliensis, and the mechanisms by which it causes disease remain unclear.


PstI Site Flagellin Gene Human Faecal Samples3 Flagellin Protein Flagellin Subunit 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Fox, J. O., Maxwell, K. O., Taylor, N. S., Runsick, C. D., Edmunds, P., & Brenner, D. J. (1989). J. Clin. Microbiol, 27, 2376–2378.PubMedGoogle Scholar
  2. 2.
    Gaudreau, C., & Lamothe, F. (1992). J. Clin. Microbiol, 30(5), 1354–1356.PubMedGoogle Scholar
  3. 3.
    Goossens, H., Pot, B., Vlaes, L., Van Den Borre, C., Van Den Abbelle, R., Van Naelten, C., Levy, J., Cog-niau, H., Marbehant, P., Verhoef, J., Kersters, K., Butzler, J., & Vandamme, P. (1990). J. Clin. Microbiol, 1039-1046.Google Scholar
  4. 4.
    Gurgan, T., & Diker, K. S. (1994). J. Clin. Microbiol, 32(12), 3093–3094.PubMedGoogle Scholar
  5. 5.
    Lastovica, A. J., Le Roux, E., & Penner, J. L. (1989). J. Clin Microbiol, 27(4), 657–659.PubMedGoogle Scholar
  6. 6.
    Megraud, F., & Bonnet, F. (1986). J. Infect, 12, 75–276.CrossRefGoogle Scholar
  7. 7.
    Patton, C. M., Shaffer, N., Edmonds, P., Barrett, T. J., Lambert, M. A., Baker, C., Perlman, D. M., & Brenner, D. J. (1989). J. Clin. Microbiol, 27(1), 66–73.PubMedGoogle Scholar
  8. 8.
    Sandstedt, K., Ursing, J., & Walder, M. (1983). Curr Microbiol, 8, 209–213.CrossRefGoogle Scholar
  9. 9.
    Steele, T. W., Sangster, N., & Lanser, J. A. (1985). J. Clin. Microbiol, 22, 71–74.PubMedGoogle Scholar
  10. 10.
    Taylor, D. E., Hiratsuka, H., & Mueller, L. (1989). J. Clin. Microbiol, 27(9), 2042–2045.PubMedGoogle Scholar
  11. 11.
    Walmsley, S. L., & Karmali, M. A. (1989). J. Clin. Microbiol, 27(4), 668–670.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • J. M. Cox
    • 1
  • J. M. Ketley
    • 2
  • P. H. Williams
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of LeicesterLeicesterUK
  2. 2.Department of GeneticsUniversity of LeicesterLeicesterUK

Personalised recommendations