Regulation of Oligodendrocyte Differentiation by Fibroblast Growth Factors

  • Rashmi Bansal
  • S. E. Pfeiffer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 429)


The interface between proliferation and differentiation is a key point of regulation in development. Among elements of the environment that influence these alternative states is a structurally related family of fourteen polypeptides (see references in Coulier et al., 1997), the fibroblast growth factors, half of which are expressed in the brain. These growth factors play crucial roles in both normal physiological (such as embryonic and postnatal development, nervous system differentiation, angiogenesis and wound repair) and pathological (such as tumorogenesis and metastasis) processes (reviewed in Basilico and Moscatelli, 1992; Eckenstein, 1994). The most extensively studied member of this family, FGF-2 (commonly known as basis fibroblast growth factor), targets a broad spectrum of cell types derived from mesoderm and neuroectoderm. It induces a variety of biological activities, such as the inhibition or stimulation of differentiation, proliferation, chemotaxis, enhanced survival and cytoskeletal alterations.


Fibroblast Growth Factor Fibroblast Growth Factor Receptor Basic Fibroblast Growth Factor Mature Oligodendrocyte Oligodendrocyte Differentiation 


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Rashmi Bansal
    • 1
  • S. E. Pfeiffer
    • 1
  1. 1.Departments of Pharmacology and Microbiology, and Program in Neurological SciencesUniversity of Connecticut Medical SchoolFarmingtonUSA

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