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Brain Plasticity pp 305–322Cite as

Brain Plasticity and the Neural Cell Adhesion Molecule (NCAM)

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 429))

Abstract

NCAM is a member of the Ig superfamily that is highly expressed in the nervous system. NCAM mediates cell-cell adhesion and adhesion of cells to the extracellular matrix. In addition to influencing the adhesive behaviour of cells, NCAM binding triggers the activation of intracellular signalling pathways. It is well established that NCAM is important for the formation of proper neuronal connections in the developing nervous system. Recently, plasticity of neuronal connections in the mature brain has also been shown to be dependent on NCAM function.

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Authors and Affiliations

  1. The Protein Laboratory, Institute for Molecular Pathology, Panum Institute bld. 6.2., Blegdamsvej 3, 2200, Copenhagen N, Denmark

    Lars Christian B. Rønn, Nina Pedersen, Vladimir Berezin & Elisabeth Bock

  2. Department for Neurophysiology, Panum Institute bld. 16.5., Blegdamsvej 3, 2200, Copenhagen N., Denmark

    Henrik Jahnsen

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  2. Nina Pedersen
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  3. Henrik Jahnsen
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  4. Vladimir Berezin
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  5. Elisabeth Bock
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Correspondence to Lars Christian B. Rønn .

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  1. University of Torino, Torino, Italy

    Guido Filogamo

  2. University of Colorado Health Sciences Center, Denver, Colorado, USA

    Antonia Vernadakis

  3. University of Cagliari, Cagliari, Italy

    Fulvia Gremo

  4. Université Montpellier II, Montpellier, France

    Alain M. Privat

  5. University of California, Berkeley, California, USA

    Paola S. Timiras

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Rønn, L.C.B., Pedersen, N., Jahnsen, H., Berezin, V., Bock, E. (1997). Brain Plasticity and the Neural Cell Adhesion Molecule (NCAM). In: Filogamo, G., Vernadakis, A., Gremo, F., Privat, A.M., Timiras, P.S. (eds) Brain Plasticity. Advances in Experimental Medicine and Biology, vol 429. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9551-6_22

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