Brain Plasticity and the Neural Cell Adhesion Molecule (NCAM)

  • Lars Christian B. RønnEmail author
  • Nina Pedersen
  • Henrik Jahnsen
  • Vladimir Berezin
  • Elisabeth Bock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 429)


NCAM is a member of the Ig superfamily that is highly expressed in the nervous system. NCAM mediates cell-cell adhesion and adhesion of cells to the extracellular matrix. In addition to influencing the adhesive behaviour of cells, NCAM binding triggers the activation of intracellular signalling pathways. It is well established that NCAM is important for the formation of proper neuronal connections in the developing nervous system. Recently, plasticity of neuronal connections in the mature brain has also been shown to be dependent on NCAM function.


Synaptic Plasticity Dentate Gyrus Neurite Outgrowth Neural Cell Adhesion Molecule Brain Plasticity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Lars Christian B. Rønn
    • 1
    Email author
  • Nina Pedersen
    • 1
  • Henrik Jahnsen
    • 2
  • Vladimir Berezin
    • 1
  • Elisabeth Bock
    • 1
  1. 1.The Protein Laboratory, Institute for Molecular PathologyPanum Institute bld. 6.2.Copenhagen NDenmark
  2. 2.Department for NeurophysiologyPanum Institute bld. 16.5.Copenhagen N.Denmark

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