Regulation by Neurotransmitters of Glial Energy Metabolism

  • Pierre J. Magistretti
  • Luc Pellerin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 429)


Astrocytes are ideally positioned to couple neuronal activity with energy metabolism. Thus particular astrocytic profiles, the end-feet, surround intraparenchymal capillaries, implying that they form the first cellular barrier that energy substrates entering the brain parenchyma, in particular glucose, encounter. In addition, astrocytes possess receptors and reuptake sites for neurotransmitters, and astrocytic processes ensheath synaptic contacts: these features imply that astrocytes are ideally positioned to sense increases in synaptic activity and to couple them with energy metabolism. We have characterized three metabolic processes regulated by neurotransmitters in primary astrocyte cultures prepared from neonatal mouse cerebral cortex: glycogenolysis, glycogen resynthesis and glycolysis.


Vasoactive Intestinal Peptide Glucose Utilization Aerobic Glycolysis Functional Brain Imaging Astrocytic Process 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Pierre J. Magistretti
    • 1
  • Luc Pellerin
    • 1
  1. 1.Laboratoire de Recherche Neurologique Institut de Physiologie et Service de Neurologie du CHUV Faculté de MédecineUniversité de LausanneLausanneSwitzerland

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