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Effects of Intramuscular Injection of Botulinum Toxin Type B in Nonhuman Primates

  • E. D. Moyer
  • E. A. Stephens
  • F. Esch
  • M. Litwak
  • J. Arezzo

Abstract

Botulinum Toxin Type B (Bot B) is proposed as a therapeutic agent for the treatment of uncontrolled contractions of specific muscles in the shoulder and neck, associated with the disease, cervical dystonia. When injected into specific muscles, Botulinum Toxin Type B is expected to produce a localized pre-synaptic neuromuscular block by preventing release of acetylcholine from nerve endings, reducing the excessive muscle contractions characteristic of cervical dystonia.

Keywords

Nonhuman Primate Cynomolgus Monkey Specific Muscle Cervical Dystonia Compound Muscle Action Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • E. D. Moyer
    • 1
  • E. A. Stephens
    • 2
  • F. Esch
    • 1
  • M. Litwak
    • 3
  • J. Arezzo
    • 3
  1. 1.Athena NeurosciencesSouth San FranciscoUSA
  2. 2.Michigan Department of Public HealthLansingUSA
  3. 3.Albert Einstein College of MedicineBronxUSA

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