Abstract
Botulinum A toxin injection into muscle is an important form of therapy for focal dystonias, including blepharospasm. The basis for the effect of botulinum toxin is paralysis of muscle by blocking neuromuscular transmission, as discussed elsewhere in this volume. The block of neuromuscular transmission produces functional muscle denervation. Muscle denervation stimulates changes in terminal motor axons and neuromuscular junctions, which can, in some types of denervation, be a repair process. This paper will discuss the morphology of motor nerve terminals and neuromuscular junctions following two types of denervation, the morphology the neuromuscular junction following botulinum toxin in experimental animals, and the response of the human neuromuscular junction to injection of botulinum toxin.
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© 1993 Springer Science+Business Media New York
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Alderson, K. (1993). Motor Nerve Terminal Morphology Following Botulinum a Toxin Injection in Humans. In: DasGupta, B.R. (eds) Botulinum and Tetanus Neurotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9542-4_7
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DOI: https://doi.org/10.1007/978-1-4757-9542-4_7
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