Abstract
Tetanus toxin binds with high affinity to fixation sites at the nerve terminal membrane. As a result the toxin molecule is internalized and transported retrogradely within the axon to the central nervous system (CNS). This neurotoxin is a “neurotropic” agent, since it is endowed with the capacity to migrate selectively to the CNS.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Besançon F, Ankel H. Binding of interferon to gangliosides. Nature 1974; 252: 478.
Bizzini B, Turpin A, Raynaud M. Production et purification de la toxine tétanique. Ann Inst Pasteur (Paris) 1969; 116: 686.
Bizzini B, Grob P, Akert K. Papain-derived fragment IIc of tetanus toxin: its binding to isolated synaptic membranes and retrograde axonal transport. Brain Res 1981; 210: 291.
Bizzini B, Toth P, Fedinec AH. Defining a region on tetanus toxin responsible for neuromuscular blockade. Toxicon 1988; 26: 309.
Conti C, Tsiang H. Effect of concanavalin A on the early events of rabies virus infection of CER cells. Intervirol 1985; 24: 166.
Conti C, Hauttecoeur B, Morelec MJ, Bizzini B, Orsi N, Tsiang M. Inhibition of rabies virus infection by a soluble membrane fraction from the rat central nervous system. Arch Virol 1988; 98: 73.
Cook ML, Stevens JG. Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infect Immun 1973; 34: 272.
Dumas M, Schwab ME, Thoenen H. Retrograde axonal transport of specific molecules as a tool for characterizing nerve terminal membrane, J Neurobiol 1979; 10: 179.
Fedinec AA. Studies on the mode of the spread of tetanus toxin in experimental animal. In: Raudonat HW, ed. Recent Advances in the Pharmacology of Toxins. Oxford: Pergamon, 1965.
Fillenz M, Gagnon C, Stoeckel K, Thoenen H. Selective uptake and retrograde axonal transport of dopamine beta-hydroxylase antibodies in peripheral adrenergic neurons. Brain Res 1976; 114: 293.
Guillon JC. Un modèle expérimental d’infection herpétique: l’infection cutanée Herpesvirus eidolon (nov. sp.) chez la souris. Sci Tech Anim Lab 1976; 1, n°2:79.
Habermann E. 1251-labelled neurotoxin from Clostridium botulinum A. Preparation binding to synaptosomes and ascent to the spinal cord. Naunyn-Schmiedeberg’s Arch Pharmacol 1974; 281:47.
Harper CG, Gonatas JO, Stieber A, Gonatas NK. In vivo uptake of wheat germ agglutinin-horse radish peroxydase conjugates into neuronal GERL and lysosomes. Brain Res 1980; 188: 465.
Hendry IA, Stoeckel K, Thoenen H, Iversen LL. The retrograde axonal transport of nerve growth factor. Brain Res 1974; 68: 103.
Kristensson K, Lycke E, Sjöstrand J. Spread of herpes simplex virus in peripheral nerves. Acta Neuropath 1971; 17: 44.
Knypers HGJM, Ugolini G. Viruses as transneuronal tracers. Trends in Neurosci 1990; 13: 71.
Marconi P, Pitzurra M, Vecchiarelli A, Pitzurra L, Bistoni F. Resistance induced by concanavalin A and phytohaemagglutinin P against tetanus toxin in mice. Ann. Immunol (Inst Pasteur) 1982; 133D: 15.
Matsuda M, Yoneda M. Isolation and purification of two antigenically active “complementary” polypeptide fragments of tetanus neurotoxin. Infect Immun 1975; 12: 1147.
Severin MJ, White RJ. The neural transmission of herpes simplex virus in mice. Am J Pathol 1968; 53: 1009.
Stoeckel K, Schwab M, Thoenen H. Role of gangliosides in retrograde axonal transport of tetanus and cholera toxin. Experientia 1971; 32: 783.
Stoeckel K, Paravicini U, Thoenen H. Specificity of the retrograde axonal transport of nerve growth factor. Brain Res 1974; 76: 413.
Stoeckel K, Schwab M, Thoenen H. Comparison between the retrograde axonal transport of growth factor and tetanus toxin in motor, sensory and adrenergic neurons. Brain Res 1975; 99: 1.
Stoeckel K, Schwab ME, Thoenen H. Role of gangliosides in the uptake and retrograde axonal transport of cholera and tetanus toxin as compared to nerve growth factor and wheat germ agglutinin. Brain Res 1977; 132: 273.
Superti F, Hauttecoeur B, Morelec MJ, Goldoni P, Bizzini B, Tsiang MJ. Involvement of gangliosides in rabies virus infection. J Gen Virol 1986; 67: 47.
Taylor CF, Britton P, Van Heyningen S. Similarities in the heavy and light chains of tetanus toxin suggested by their amino acid composition. Biochem J 1983; 209: 897.
Tsiang H. Evidence for an intraaxonal transport of fixed and street rabies virus. J Neuropath Exp Neurol 1979; 38: 286.
Tsiang H, Koulakoff A, Bizzini B, Berwald-Netter Y. Neurotropism of rabies virus. An in vitro study of neurons and glia. J Neuropath Exp Neurol 1983; 42: 439.
Van Heyningen WE, Miller PA. The fixation of the tetanus toxin by ganglioside, J Gen Microbiol 1961; 24: 107.
Wiegand H, Erdmann G, Wellhöner HH. 125I-labelled botulinum A neurotoxin: pharmacokinetics in cats after intramuscular injection. Naunyn-Schmiedeberg’s Arch Pharmacol 1976; 292: 161.
Wildy P. The progression of herpes simplex virus to the CNS of the mouse. J Hyg 1967; 65: 173.
Young AB, Snyder SH. Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci (Wash) 1973; 70: 2832.
Ziegler MG, Thomas JA, Jacobowitz DM. Retrograde axonal transport of antibody to dopamine betahydroxylase. Brain Res 1976; 104: 390.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bizzini, B., Khiri, M., Carlotti, M. (1993). Tetanus Toxin as a Tool for Investigating the Structural Bases of Neurotropism. In: DasGupta, B.R. (eds) Botulinum and Tetanus Neurotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9542-4_5
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9542-4_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9544-8
Online ISBN: 978-1-4757-9542-4
eBook Packages: Springer Book Archive