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Structure of Botulinum Neurotoxin Channels in Phospholipid Vesicles

  • M. F. Schmid
  • J. P. Robinson
  • B. R. DasGupta

Abstract

Botulinum neurotoxins comprise a class of potent inhibitors of neurotransmitter release, thus acting presynaptically. Their function has been biochemically dissected into distinct stages: i) cell surface attachment; ii) internalization via the endocytotic/lysosomal vesicle pathway; iii) penetration into the cytoplasm from these vesicles through a pH-dependent conformational change; and iv) intracellular poisoning.1 There are seven distinct serotypes, some of which have been sequenced.2

Keywords

Vesicle Wall Botulinum Neurotoxin Tetanus Toxin Clostridium Botulinum Distinct Serotypes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Simpson LL, ed. Botulinum neurotoxin and tetanus toxin. San Diego: Academic Press, 1989.Google Scholar
  2. 2.
    Whelan SM, Elmore MJ, Bodsworth NJ, Brehm JK, Atkinson T, Minton NP. Molecular cloning of the Clostridium botulinum structural gene encoding the type B neurotoxin and determination of its entire nucleotide sequence. Appl Environ Microbiol 1992; 58: 2345–2354.PubMedGoogle Scholar
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    Simpson LL. Molecular pharmacology of botulinum toxin and tetanus toxin. Ann Rev Pharmacol Toxicol 1986; 26: 427–453.CrossRefGoogle Scholar
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    Kornberg RD, Darst SA. Two dimensional crystals of proteins on lipid layer. Curt Op Struc Biol 1991; 1: 642–646.CrossRefGoogle Scholar
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    DeRosier DJ, Moore PB. Reconstruction of three dimensional images from electron micrographs of structures with helical symmetry. J Mol Biol 1970; 52: 355–369.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • M. F. Schmid
    • 1
  • J. P. Robinson
    • 1
  • B. R. DasGupta
    • 2
  1. 1.Verna and Marrs McLean Department of BiochemistryBaylor College of MedicineHoustonUSA
  2. 2.Department of Food Microbiology and ToxicologyUniversity of Wisconsin-MadisonMadisonUSA

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