Structure of Botulinum Neurotoxin Channels in Phospholipid Vesicles
Botulinum neurotoxins comprise a class of potent inhibitors of neurotransmitter release, thus acting presynaptically. Their function has been biochemically dissected into distinct stages: i) cell surface attachment; ii) internalization via the endocytotic/lysosomal vesicle pathway; iii) penetration into the cytoplasm from these vesicles through a pH-dependent conformational change; and iv) intracellular poisoning.1 There are seven distinct serotypes, some of which have been sequenced.2
KeywordsVesicle Wall Botulinum Neurotoxin Tetanus Toxin Clostridium Botulinum Distinct Serotypes
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- 1.Simpson LL, ed. Botulinum neurotoxin and tetanus toxin. San Diego: Academic Press, 1989.Google Scholar