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Thoughts on Action of Botulinum Toxin Suggested by Reversibility of Heart Effects

  • Carl Lamanna

Abstract

Botulinum neurotoxin poisoning prevents the release of the neurotransmitter acetylcholine into the synaptic cleft. Stimulation of the cholinergic nerve is required for the acetylcholine-containing vesicles to attach to the inner surface at specific points of the nerve cell synaptic membrane. Thereupon at these points of attachment the acetylcholine leaves the vesicles to escape into the synaptic cleft by passage across the synaptic membrane. This event has been called exocytosis and is probably the action frustrated by the presence of toxin.

Keywords

Synaptic Cleft Synaptic Membrane Cholinergic Nerve Isolate Heart Preparation Tetanus Neurotoxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Duchen LW, Strich SJ. The effects of botulinum toxin on the pattern of innervation of skeletal muscle in the mouse. Quart J Exp Physiol Cogn Med Sci 1968; 53: 84–89.Google Scholar
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    Lamanna C. Overview of bacterial toxins with a nonreductionist approach to the mode of action of botulinal neurotoxin. In: Pohland AE et al., eds. Microbial toxins in foods and feeds. New York: Plenum Press, 1990.Google Scholar
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    Lamanna C, El-Hage AN, Vick JA. Cardiac effects of botulinal toxin. Arch Int Pharmacodyn Therap 1988; 293: 69–83.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Carl Lamanna
    • 1
  1. 1.Carolina Meadows V267Chapel HillUSA

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