PC12 Cells as a Model for Neuronal Secretion

  • Paul D. Wagner
  • Ngoc-Diep Vu
  • You Neng Wu


PC12 cells are widely used as models for both neuroendocrine secretion and neuronal differentiation. In this article we will briefly review the origin of these cells and the various types of experiments in which they are employed. We will then discuss in some detail their use as a model for neuronal secretion. There are several extensive and authoritative reviews on PC12 cells which provide much more detailed information on the origin, differentiation, and biochemical properties of PC12 cells.1–4


PC12 Cell Nerve Growth Factor Chromaffin Cell Botulinum Neurotoxin Tetanus Toxin 


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Paul D. Wagner
    • 1
  • Ngoc-Diep Vu
    • 1
  • You Neng Wu
    • 1
  1. 1.Laboratory of Biochemistry National Cancer InstituteNational Institutes of HealthBethesdaUSA

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