Sda and Cad Antigens

  • Winifred M. Watkins
Part of the Blood Cell Biochemistry book series (BLBI, volume 6)


In 1967 two independent groups (Renton et al., 1967; Macvie et al., 1967) recognized that a number of human red cell antibodies under investigation in different laboratories, belonged to a single system which has come to be known as the Sid blood group system. The antibodies in general gave only weak and rather nebulous reactions and were distinguished by the property of agglutinating only a proportion of a donor’s erythrocytes, even those of the more strongly positive reactors. The system has only one antigen Sda, and hence there are two phenotypes Sda(a+) and Sda(—): of the British population initially studied about 92% were Sd(a+) (Table I). Of these positive individuals only 1% gave relatively strong reactions, 80% gave distinct compact small agglutinates in a field of unagglutinated cells, and 10% gave very weak tiny agglutinates (Renton et al., 1967; Macvie et al., 1967; Pickles and Morton, 1977). Separation of the Sda-positive cells from the unagglutinated cells, followed by exposure of the remaining cells to more anti-Sda, gives a mixed field picture once more; indicating that the majority of cells carry the antigen but in variable amounts (Macvie et al., 1967).


Sialic Acid Blood Group Blood Group Antigen Oligosaccharide Chain Blood Group System 
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© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Winifred M. Watkins
    • 1
  1. 1. Department of Haematology, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK

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