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Expression of Human Erythrocyte Membrane Protein Antigens during Erythroid Differentiation

  • Marilyn J. Telen
Part of the Blood Cell Biochemistry book series (BLBI, volume 1)

Abstract

Recent advances in hybridoma technology, fluorescence-activated cell sorting, and bone marrow culture techniques have led to investigations of the manner in which blood group antigens and other cell surface molecules are expressed during hematopoietic differentiation. These studies have demonstrated expression by erythroid progenitors and precursors of molecules or epitopes unique to the erythroid lineage as well as of other molecules whose expression is shared by precursor cells of other lineages. Some antigens are expressed by progenitor cells but lost during differentiation, while other antigens appear first during intermediate and late stages of erythropoiesis.

Keywords

Paroxysmal Nocturnal Hemoglobinuria Erythroid Cell Erythroid Progenitor Erythroid Differentiation Blood Group Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Marilyn J. Telen
    • 1
  1. 1.Division of Hematology/Oncology, Department of Medicine, and Immunohematology Laboratory, Transfusion ServiceDuke University Medical CenterDurhamUSA

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