Receptors for Erythropoietin Distribution, Structure, and Role in Receptor-Mediated Endocytosis in Erythroid Cells

  • Stephen T. Sawyer
Part of the Blood Cell Biochemistry book series (BLBI, volume 1)

Abstract

Erythropoietin (EP) is the glycoprotein hormone that is the primary regulator of red cell development. It is synthesized and released from the kidneys and livers of animals and man in response to a deficit of oxygen. Erythroid precursor cells respond to the hormone through surface receptors by maturing to functional erythrocytes. Increased erythrocytes in turn result in an increased availability of oxygen. The increased oxygen in the tissues leads to a decrease in synthesis and release of EP. These events comprise the elements of the reflex pathway that is the primary if not exclusive control of normal erythropoiesis. Normally the need for new erythrocytes is small and the circulating levels of the hormone are quite low; however, a decreased delivery of oxygen through hemorrhage, high-altitude hypoxia, red cell disorders, and other causes results in up to 1000-fold induction of the mRNA encoding EP in the kidney and a corresponding increase in the circulating levels of the hormone.

Keywords

Carbohydrate DMSO Cobalt Leukemia Carbon Monoxide 

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Stephen T. Sawyer
    • 1
  1. 1.Division of Hematology, Department of MedicineVanderbilt University School of MedicineNashvilleUSA

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