Recovery of Basophils and Mast Cells from Degranulation
Abundant morphologic evidence now exists that neither anaphylactic degranulation (AND) nor piecemeal degranulation (PMD) results in the death of basophils or mast cells (A. M. Dvorak, 1988a,b, 1989a,b; Galli et al., 1984, 1990). Rather, and like secretory cells in general, basophils and mast cells survive these release events. In AND, a completely degranulated cell has diminished numbers of entire granules, i.e., both the contents and the containers, whereas in PMD, a completely degranulated cell has released the contents of the granules and retained the containers. Recovery (after AND) of containers and contents or (after PMD) of contents, then, may be necessary if these viable cells are to renew their secretory functions.
KeywordsMast Cell Rough Endoplasmic Reticulum Lipid Body Human Mast Cell Recovery Event
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