Advertisement

The Controlled Release of a 5-Fluorouracil Prodrug from a Biodegradable Matrix

  • Charles G. Gebelein
  • Donna Gardner
  • Tonya Ellis

Abstract

A prodrug of 5-fluorouracil [5-FU] was prepared by reacting a 5-FU slurry with hexylisocyanate, in dioxane, at room temperature. The resulting solid, called HIFU, was purified and the release rates of 5-FU were determined, in distilled water, and compared against 5-FU using the gas dispersion tube technique previously described, at both room temperature and at 37°C. HIFU was studied in the form of a powder and as a monolithic dispersion in poly(caprolactone), The prodrug releases 5-FU very rapidly in the powdered form and both HIFU and 5-FU gave the typical monolithic release profiles, which were linear when plotted against the square root of time.

Keywords

Methyl Acrylate Biomedical Polymer Monolithic Sample Monolithic System Biodegradable Matrix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    C. G. Gebelein, Proc. Polym. Mat. Sci. Eng., 51, 127–131 (1984).Google Scholar
  2. 2.
    R. R. Hartsough & C. G. Gebelein, Proc. Polym. Mat. Sci. Eng., 51, 131–135 (1984).Google Scholar
  3. 3.
    R. R. Hartsough & C. G. Gebelein in: “Polymeric Materials in Medication, C. G. Gebelein & C. E. Carraher, Jr., Eds., Plenum Publ. Corp., New York, 1985, pp. 115–124.Google Scholar
  4. 4.
    C. G. Gebelein & R. R. Hartsough in: “Controlled Release of Bioactive Materials, 11th International Symposium,” W. E. Meyers & R. C. Dunn, Eds., Controlled Release Society, Lincolnshire, IL, 1984, pp. 65–66.Google Scholar
  5. 5.
    C. G. Gebelein, T. Mirza & M. Chapman, Proc. Polym. Mat. Sci. Eng., 57, 413–416 (1987).Google Scholar
  6. 6.
    C. G. Gebelein, R. R. Hartsough & T. Mirza in: “Controlled Release of Bioactive Materials, 13th International Symposium, I. A. Chaudry & C. Thies, Eds., Controlled Release Society, Lincolnshire, IL, 1986, pp. 188–189.Google Scholar
  7. 7.
    C. G. Gebelein, T. Mirza & R. R. Hartsough in: “Controlled Release Technology, Pharmaceutical Applications, P. I. Lee and W. R. Good, Eds., Symp. Series #348, American Chemical Society, Washington, DC, 1987, pp. 120–126.Google Scholar
  8. 8.
    C. G. Gebelein, M. Chapman & T. Mirza in: “Applied Bioactive Polymeric Systems, C. G. Gebelein, C. E. Carraher & V. Foster, Eds., Plenum Publ., New York, 1988, pp. 151–163.Google Scholar
  9. 9.
    C. G. Gebelein, M. Davison, T. Gober & M. Chapman, Proc. Polym. Mat. Sci. Eng., 59, 798–802 (1988).Google Scholar
  10. 10.
    C. G. Gebelein, M. Chapman, M. Davison & T. Gober, in: “Progress in Biomedical Polymers, C. G. Gebelein & R. L. Dunn, Eds., Plenum Publ. Corp., New York, 1990, pp. 321–334.Google Scholar
  11. 11.
    T. Higuchi, J. Pharm. Sci., 59, 353 (1961).Google Scholar
  12. 12.
    M. Yoshida, M. Kumakura & I. Kaetsu, Polymer, 19, 1375 (1978).CrossRefGoogle Scholar
  13. 14.
    M. Yoshida, M. Kumakura & I. Kaetsu, Polymer, 11, 775 (1979).CrossRefGoogle Scholar
  14. 15.
    I. Kaetsu, M. Yoshida, M. Kumakura, A. Yamada & Y. Sakurai, Biomaterials, 1, 17 (1980).PubMedCrossRefGoogle Scholar
  15. 16.
    I. Kaetsu, M. Yoshida & A. Yamada, J. Biomed. Mater. Res., 14, 185 (1980).CrossRefGoogle Scholar
  16. 17.
    M. Ghosh in: “Progress in Biomedical Polymers, C. G. Gebelein & R. L. Dunn, Eds., Plenum Publ. Corp., New York, 1990, pp. 335–345.Google Scholar
  17. 18.
    C. G. Gebelein, D. Williams, K. Marshall and T. Slaven, This book.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Charles G. Gebelein
    • 1
    • 3
    • 4
    • 5
  • Donna Gardner
    • 2
  • Tonya Ellis
    • 2
  1. 1.Department of ChemistryYoungstown State UniversityYoungstownUSA
  2. 2.Department of Chemical EngineeringYoungstown State UniversityYoungstownUSA
  3. 3.Department of ChemistryFlorida Atlantic UniversityBoca RatonUSA
  4. 4.LIONFIRE, Inc.EdgewaterUSA
  5. 5.LIONFIRE, Inc.EdgewaterUSA

Personalised recommendations