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The Release of 5-Fluorouracil from Dextran and Xylan Systems

  • Charles G. Gebelein
  • Darrell Williams
  • Kathy Marshall
  • Terri Slaven

Abstract

As part of a continuing study on the controlled release of anticancer agents, 5-fluorouracil:poly(saccharide) adducts were synthesized and their release profiles were determined. The poly(saccharides) studied included dextran (15,000 and 60,000 molecular weight), xylan and chitosan. The 5-FU was attached to the poly(saccharides) using 1,6-diisocyanatohexane as the coupling agent. In all cases, the release of the 5-FU was rapid and was essentially complete within a few days, when the adducts were prepared using a triethylamine catalyst system. The kinetic patterns were neither true Higuchi style plots, which are typical of monolithic systems, nor were they zero-order profiles like previously described methacrylate-type copolymers. When a tin catalyst was used, however, the 5-FU was released over a much longer time period, and the release profile was linear when plotted against the square root of time. Only these tin catalyzed adducts are potentially useful in controlled release of 5-FU.

Keywords

Control Release Release Profile Repeat Unit Methyl Acrylate Butyl Acrylate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Charles G. Gebelein
    • 1
    • 3
    • 4
    • 5
  • Darrell Williams
    • 2
  • Kathy Marshall
    • 2
  • Terri Slaven
    • 2
  1. 1.Department of ChemistryYoungstown State UniversityYoungstownUSA
  2. 2.Department of Chemical EngineeringYoungstown State UniversityYoungstownUSA
  3. 3.Department of ChemistryFlorida Atlantic UniversityBoca RatonUSA
  4. 4.LIONFIRE, Inc.EdgewaterUSA
  5. 5.LIONFIRE, Inc.EdgewaterUSA

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