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Biodegradable Polymers for the Controlled Delivery of Vaccines

  • E. Schmitt
  • D. R. Flanagan
  • R. J. Linhardt

Abstract

New methods for the efficient and effective administration of vaccines are required particularly with the advent of new synthetic subunit vaccines. This chapter describes the approaches of several research groups to administer vaccines using biodegradable polymer carriers. Delivery systems composed of synthetic poly[esters] and poly[iminocarbonates] and natural (crosslinked serum albumin) biodegradable polymers are described. The antibody levels in response to these systems are presented, and possible mechanisms responsible for the observed effects are discussed. The important questions that need to be answered before this technology can be successfully applied are also discussed.

Keywords

Release Profile Biodegradable Polymer Release Kinetic Glycolic Acid Secondary Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    R. J. Linhardt, in: “Controlled Release of Drugs: Polymers and Aggregate Systems,” M. Rosoff, Ed., VCH Publishers, New York, 1989, p. 53.Google Scholar
  2. 2.
    D. H. Lewis, in: “Biodegradable Polymers as Drug Delivery Systems,” M. Chasin & R. Langer, Eds., Marcel Dekker, Inc., New York, 1990, Chapter 1, p. 27.Google Scholar
  3. 3.
    D. W. Barry, E. Stanton, & R. E. Maynor, Infect. Immun., 10, 1329 (1974)PubMedGoogle Scholar
  4. 4.
    H. T. Wang, E. Schmitt, D. R. Flanagan & R. J. Linhardt, J. Controlled Release, 17, 23 (1991).CrossRefGoogle Scholar
  5. 5.
    H. T. Wang, H. Palmer, D. R. Flanagan, and E. Schmitt, Biomaterials, 11, 679 (1990).PubMedCrossRefGoogle Scholar
  6. 6.
    T. M. S. Chang, J. Bioeng., 1, 25 (1976).Google Scholar
  7. 7.
    R. S. Langer & I. Preis, J. Immunol. Methods, 28, 193 (1979).PubMedCrossRefGoogle Scholar
  8. 8.
    J. Kohn, S. M. Niemi, E. C. Albert, J. C. Murphy, R. Langer & J. G. Fox, J. Immunol. Methods, 95, 31 (1986).PubMedCrossRefGoogle Scholar
  9. 9.
    A. C. Miller & E. C. Tees, Clin. Allergy, 4, 49 (1974).PubMedCrossRefGoogle Scholar
  10. 10.
    R. A. Miller, J. M. Brady & D. E. Cutright, J. Biomed. Mater. Res., 11, 711 (1977).CrossRefGoogle Scholar
  11. 11.
    D. T. O’Hagan, D. Rahman, J. P. McGee, H. Jeffery, M. C. Davies, P. Williams, S. S. Davis & S. J. Challacombe, Immunology, 73, 239 (1991).Google Scholar
  12. 12.
    D. T. O’Hagan, H. Jeffery, M. J. J. Roberts, J. P. McGee & S. S. Davis, Vaccine, 9, 768 (1991).PubMedCrossRefGoogle Scholar
  13. 13.
    J. H. Eldridge, J. K. Staas, J. A. Meulbroek, J. R. McGhee, T. R. Tice & R. M. Gilley, Molecular Immunol., 28, 287 (1991).CrossRefGoogle Scholar
  14. 14.
    J. H. Eldridge, R. M. Gilley, J. K. Staas. Z. Moldoveanu, J. A. Meulbroek & T. R. Tice, Curr. Top. Microbiol. Immun., 146, 59 (1989).CrossRefGoogle Scholar
  15. 15.
    J. H. Eldridge, J. K. Staas, J. A. Meulbroek, T. R. Tice & R. M. Gilley. Infect. Immun., 59, 2978 (1991).PubMedGoogle Scholar
  16. 16.
    L. R. Beck, C. F. Flowers, Jr., D. R. Cowsar & A. C. Tanquary, U.S. Patent 4, 756, 907 (1988).Google Scholar
  17. 17.
    L. R. Beck, C. F. Flowers, Jr., D. R. Cowsar & A. C. Tanquary, U.S. Patent 4, 732, 763 (1988).Google Scholar
  18. 18.
    Stolle Milk Biologics International, Cincinnati, Ohio, Product Bulletin (1988).Google Scholar
  19. 19.
    T. K. Lee, T. D. Sokoloski & G. P. Royer, Science, 213, 233 (1981).PubMedCrossRefGoogle Scholar
  20. 20.
    J. B. Dewar, D. A. Hendry & J. F. E. Newman. S. Afr. Med. J., 65, 564 (1984).PubMedGoogle Scholar
  21. 21.
    M. E. D. Martin, J. B. Dewar & J. F. E. Newman, Vaccine, 6, 33 (1988).PubMedCrossRefGoogle Scholar
  22. 22.
    C. Langhein & J. F. E. Newman, J. Applied Bacteriology, 63, 443 (1987).CrossRefGoogle Scholar
  23. 23.
    P. Artursson, P. Edman, T. Laakso & I. Sjöholm, J. Pharm. Sci., 73, 1507 (1984).PubMedCrossRefGoogle Scholar
  24. 24.
    P. Artursson, P. Edman & I. Sjöholm, J. Pharmacol. Exp. Ther., 231, 705 (1984).Google Scholar
  25. 25.
    P. Artursson, P. Edman & I. Sjöholm, J. Pharmacol. Exp. Ther., 234, 255 (1985).Google Scholar
  26. 26.
    P. Artursson, I. L. Martensson & I. Sjöholm, J. Pharm. Sci., 75, 697 (1986).PubMedCrossRefGoogle Scholar
  27. 27.
    H. B. Rosen, J. Chang, G. E. Wnek, R. J. Linhardt & R. Langer. Biomaterials, 4, 131 (1983).PubMedCrossRefGoogle Scholar
  28. 28.
    J. Heller, J. Controlled Release, 2, 167 (1985).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • E. Schmitt
    • 1
    • 2
  • D. R. Flanagan
    • 1
    • 2
  • R. J. Linhardt
    • 1
    • 2
  1. 1.Division of PharmaceuticsUniversity of IowaIowa CityUSA
  2. 2.Division of Medicinal and Natural Products Chemistry College of PharmacyUniversity of IowaIowa CityUSA

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