Advertisement

Temporary Skin Substitute from Non-Antigenic Dextran Hydrogel

  • Paul Y. Wang
  • Nimet A. Samji
Chapter
Part of the Polymer Science and Technology book series (POLS, volume 14)

Abstract

Accidental injury with loss of skin is considered to be a “neglected disease”, partly because of the superficial nature of damage to the protective layer of the body. Surveys conducted in the U.S. show that such injury is among the principal causes of death in North America between ages 1 and 44 [1]. In the Canadian province of Ontario, there were over 50,000 people suffered loss of skin in 1977 due to trauma (including surgical autograft), disease (e.g., ulceration) or burns from electrical, chemical or thermal agents. Patients often must change their occupations or alter their normal activities, and in addition many working or school days are lost annually through lengthy stays in hospital as well as re-admission for revision of scars. Besides pain and the high incidence of bacterial infection, loss of skin is followed by excessive evaporation of vital body fluids which initiates a series of physiological responses as illustrated schematically in the following diagram:

Keywords

Petroleum Jelly Skin Substitute Hydrogel Membrane Cotton Gauze Initial Surge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    The U. S. National Institute of Health Guide for Grants and Contracts, 6, 11, (1977)Google Scholar
  2. 2.
    G. B. Park, J. M. Courtney, A. McNair and J. D. S. Gaylor, Engineering in Medicine, 7, 11 (1978)CrossRefGoogle Scholar
  3. 3.
    H. M. Bruch, In: “Basic Problems in Burns”, R. Vrabec, Z. Konickova and J. Moserova, eds., Springer-Verlag, New York, 17 (1975)Google Scholar
  4. 4.
    P. Y. Wang, D. W. Evans, N. Samji and L. Thomas, J. Surg. Res., 28, 182 (1980)CrossRefGoogle Scholar
  5. 5.
    M. M. Zeigler, H. Maguire and C. F. Barker, J. Surg. Res., 22, 643 (1977)CrossRefGoogle Scholar
  6. 6.
    P. Nathan, E. J. Law, B. G. MacMillan, D. F. Murphy, S. H. Ronal, M. J. D’Andrea and R. A. Abrahams, Trans. Amer. Soc. Artif. Int. Organs, 22, 30 (1976)Google Scholar
  7. 7.
    P. Y. Wang, N. Samji and L. Sun, Paper presented at annual meeting, Can. Biomaterials Soc., Toronto, May 1979Google Scholar
  8. 8.
    J. Lonngren, I. J. Goldstein and K. Bywater, FEBS Letters, 68, 31 (1976)CrossRefGoogle Scholar
  9. 9.
    Sephadex-Gel Filtration in Theory and Practice“, Pharmacia, Canada, Dorval, Quebec, 4 (1974)Google Scholar
  10. 10.
    D. C. Grove and W. A. Randall, “Assay Methods of Antiobiotics”, Med. Encyclop., Inc., New York, 200 (1955)Google Scholar
  11. 11.
    P. Y. Wang and D. W. Evans, Biomat., Med. Dev., Artif. Org., 5 (3), 277 (1977)Google Scholar
  12. 12.
    P. J. Blackshear, Sci. Amer., 241 (6), 52 (1979)CrossRefGoogle Scholar
  13. 13.
    P. Y. Wang and N. Samji, Proceedings of First World Biomaterials Congress, Vienna (in press)Google Scholar
  14. 14.
    E. A. Kabat, “Structural Concepts in Immunology and Iumiunochemistry”, second ed., Holt, Rinehart and Winston, New York, 21 (1976)Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Paul Y. Wang
    • 1
  • Nimet A. Samji
    • 1
  1. 1.Institute of Biomedical Engineering Faculty of MedicineUniversity of TorontoCanada

Personalised recommendations