Advertisement

Selected Examples of Pathologic Processes Associated with Human Polymeric Implants

  • James M. Anderson
Chapter
Part of the Polymer Science and Technology book series (POLS, volume 14)

Abstract

Continuing advances in the design of prostheses and techniques for their implantation have produced impressive results in the length and quality of survival in patients who receive these polymeric prostheses or devices. With the ever increasing number of implants over the past two decades, basic and clinical scientists have used a wide and varied number of techniques to appreciate or determine the suitability of a given polymer for a given implant application. These techniques, aimed at determining the implant/host interaction, have generally been included under the term “biocompatibility”. Investigators commonly deal with biocompatibility in terms of whether the implant material or its degradation products, if any, initiate adverse tissue responses in the host or conversely whether deleterious changes in the chemical, physical and/or mechanical properties of the implant material are caused by the host environment. The vast majority of fundamental studies of biocompatibility involve animal models. The ultimate test for biocompatibility of a polymer, device or prosthesis, is human implantation. With this in mind, we have sought to examine implants and tissue obtained by surgical removal from humans or at autopsy. The simultaneous examination of polymeric implants and tissues removed from humans offers an opportunity to directly appreciate the various aspects of the implant/host interaction.

Keywords

Bone Cement Vascular Graft Fibrous Capsule Prosthetic Heart Valve Cement Interface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P. N. Sawyer and M. J. Kaplitt, editors, “Vascular Grafts”, Appleton-Century-Crofts, New York, (1978).Google Scholar
  2. 2.
    H. Dardik, editor, “Graft Materials in Vascular Surgery”, Year Book Medical Publishers, Chicago, Illinois, (1978).Google Scholar
  3. 3.
    B. C. Syrett and A. Acharya, editors, “Corrosion and Degradation of Implant Materials”, American Society for Testing and Materials, Philadelphia, Pa., (1979).Google Scholar
  4. 4.
    G. Chapchal, editor, “Arthroplasty of the Hip”, G. Thieme, Stuttgart, West Germany, (1973).Google Scholar
  5. 5.
    Total Joint Arthroplasty Symposium in Mayo Clinic Proceedings, 54, 557–601, (1979).Google Scholar
  6. 6.
    E. A. Lefrak and A. Starr, “Cardiac Valve Prostheses”, AppletonCentury-Crofts, New York, (1979).Google Scholar
  7. 7.
    R. H. Rigdon, “CRC Critical Reviews in Food Science and Nutrition”, August, 1975, p. 435.Google Scholar
  8. 8.
    D. L. Coleman, R. N. King, and J. D. Andrade, J. Biomed. Mater. Res., 8, 199, (1974).CrossRefGoogle Scholar
  9. 9.
    D. E. Ocumpaugh, and H. L. Lee, J. Macromol. Sci.-Chem., A4 (3), 595, (1970).CrossRefGoogle Scholar
  10. 10.
    S. Hirsch, H. Robertson, and M. Gornowsky, Arch. Surg., III, February (1976).Google Scholar
  11. 11.
    P. Casagrande, and P. Darahy, J. Bone and Joint Surg., 53, 167, (1971).Google Scholar
  12. 12.
    C. A. Vinnick, Plastic and Reconstructive Surgery, 58, 555 (1976).CrossRefGoogle Scholar
  13. 13.
    H. Wagner, F. K. Beller, and M. Pfautsch, Plastic and Reconstructive Surgery, 60, 49, (1977).CrossRefGoogle Scholar
  14. 14.
    R. Rudolph et al. Plastic and Reconstructive Surgery, 62, 185, (1978).CrossRefGoogle Scholar
  15. 15.
    D. E. Barker, M. I, Retsky, and S. Schultz, Plastic and Reconstructive Surgery, 61, 836, (1978).Google Scholar
  16. 16.
    R. M. Gayou, Plastic and Reconstructive Surgery, 63, 700, (1979).CrossRefGoogle Scholar
  17. 17.
    D. F. Gibbons, G. Picha, and S. R. Taylor, Unpublished results.Google Scholar
  18. 18.
    D. K. Gilding, Unpublished results.Google Scholar
  19. 19.
    H.-G. Willert, J. Ludwig, and M. Semlitsch, J. Bone and Joint Surgery, 56, 1368 (1974).Google Scholar
  20. 20.
    F. W. Reckling, M. A. Asher, and W. L. Dillon, J. Bone and Joint Surgery, 59, 355, (1977).Google Scholar
  21. 21.
    F. W. Reckling and W. L. Dillon, J. Bone and Joint Surgery, 59, 80, (1977).Google Scholar
  22. 22.
    C. D. Jefferiss, A.J.C. Lee, and R.S.M. Ling, J. Bone and Joint Surgery, 57, 511, (1975).Google Scholar
  23. 23.
    A. Florian, L. Cohn, G. Dammin, and J. Collins, Arch. Surg., 111, 267, (1976).CrossRefGoogle Scholar
  24. 24.
    C. D. Campbell, D. H. Brooks, M. W. Webster et al. Surgery, 85, 177, (1979).Google Scholar
  25. 25.
    M. P. Morgan, G. J. Dammin, and J. M. Lazarus, Trans. Am. Soc. Artif. Intern. Organs, 24, 44, (1978).Google Scholar
  26. 26.
    K. Hameed, S. Ashjaq, and D. O. W. Waugh, Arch. Path., 86, 520, (1968).Google Scholar
  27. 27.
    J. C. Hylen, F. E. Kloster, A. Starr, and H. E. Griswold, Annals of Internal Medicine, 72, 1, (1970).CrossRefGoogle Scholar
  28. 28.
    N. R. Niles, J. Thoracic and Cardiovascular Surgery, 59, 794, (1970).Google Scholar
  29. 29.
    W. E. Stamm, Annals of Internal Medicine, 89, 764, (1978).CrossRefGoogle Scholar
  30. 30.
    R. J. Duma, editor, “Infections of Prosthetic Heart Valves and Vascular Grafts”, University Park Press, Baltimore, (1977).Google Scholar
  31. 31.
    L. S. Olanoff, J. M. Anderson, and R. D. Jones, Trans. Am. Soc. Artif. Intern. Organs, 25, 334, (1979).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • James M. Anderson
    • 1
  1. 1.Departments of Pathology and Macromolecular ScienceCase Western Reserve UniversityClevelandUSA

Personalised recommendations