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Noradrenergic Function in Depressive Disorders

  • William Z. Potter
  • Fred Grossman
  • Matthew V. Rudorfer
Part of the The Depressive Illness Series book series (DISS, volume 3)

Abstract

Since the elaboration of the catecholamine hypothesis of affective disorders more than twenty years ago, researchers have attempted to test it mainly by measuring norepinephrine (NE) and 3-methoxy-4hydroxyphenyl-glycol (MHPG), a major NE metabolite in urine, plasma, and cerebrospinal fluid (CSF). MHPG is the only quantitatively significant brain NE metabolite entering the circulation and therefore had originally been thought to reflect brain “activity” (Schildkraut, Orsulak, Schatzberg, Gudeman, Cole, Rohde, & LaBrie, 1978). It was subsequently demonstrated that the CNS contributes 20%–30% of NE metabolites to the circulation. Of this, only 50% of central MHPG appears as MHPG in the urine; the remainder is metabolized to other metabolites, of which 3-methoxy-4-hydroxyvanillyl-mandelic-acid (VMA) predominates. Peripherally released NE contributes the other 50% of circulating MHPG (Filser, Spira, Fischer, Gattaz, & Muller, 1988; Kopin, 1985; Kopin, 1984). Pathways of NE metabolism are shown in Figure 1.

Keywords

Depressed Patient Suicide Victim Noradrenergic Function Unipolar Depressed Patient Plasma MHPG 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Amsterdam JD, Maislin G, Skolnick GB, Berwish N, Winokur A: Multiple hormone responses to clonidine administration in depressed patients and healthy volunteers. Biol Psychiat 1989; 26: 265–278.PubMedCrossRefGoogle Scholar
  2. Banerjee SD, King LS, Riggi SS, Chandra SK: Development of beta-adrenergic receptor subsensitivity by antidepressants. Nature 1977; 268: 455–456.PubMedCrossRefGoogle Scholar
  3. Beckmann H, Goodwin FK: Urinary MHPG in subgroups of depressed patients and normal controls. Neuropsychobiol 1980; 6: 91–100.CrossRefGoogle Scholar
  4. Bergstrom DA, Kellar KJ: Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain. Nature 1979; 278: 464–466.PubMedCrossRefGoogle Scholar
  5. Biegon A, Israeli M: Regionally selective increases in beta-adrenergic receptor density in the brains of suicide victims. Brain Research 1988; 442: 199–203.PubMedCrossRefGoogle Scholar
  6. Boyajian CL, Leslie FM: Pharmacological evidence for alpha2 adrenoceptor heterogeneity: Differential binding properties of [3H]rauwolscine and 13H]idazoxan in rat brain. J Pharmacol Exp Ther 1987; 241: 1092–1098.PubMedGoogle Scholar
  7. Bricca G, Dontenwill M, Molines A, Feldman J, Belcourt A, Bousquet P: Evidence for the existence of a homogeneous population of imidazoline receptors in the human brainstem. Eur J Pharmacol 1988; 150: 401–402.PubMedCrossRefGoogle Scholar
  8. Bricca G, Dontenwill M, Molines A, Feldman J, Belcourt A, Bousquet P: The imidazoline preferring receptor: Binding studies in bovine, rat, and human brain-stem. Eur J Pharmacol 1989; 162: 1–9.PubMedCrossRefGoogle Scholar
  9. Buckholtz NS, Davies, AO, Rudorfer MV, Golden RN, Potter WZ: Lymphocyte beta-adrenergic function versus catecholamines in depression. Biol Psychiat 1988; 24 451–457.PubMedCrossRefGoogle Scholar
  10. Campbell IC, McKernan RM, Checkley SA, Glass IB, Thompson C, Shur E: Characterization of platelet alpha2 adrenoceptors and measurement in control and depressed subjects. Psychiat Res 1986; 14: 17–31.CrossRefGoogle Scholar
  11. Carlsson A, Svennerholm L, Winblad B: Seasonal and circadian monamine variations in human brains examined post mortem. Picta Psychiat Scand 1980; 61: 75–83.Google Scholar
  12. Carstens ME, Engelbrecht AH, Russell VA, Van Zyl AM, Taljaard JJF: Biological markers in juvenile depression. Psychiat Res 1988; 23: 77–88.CrossRefGoogle Scholar
  13. Charney DS, Heninger GR: Abnormal regulation of noradrenergic function in panic disorders. Arch Gen Psychiat 1986; 43: 1041–1054.Google Scholar
  14. Charney DS, Heninger GR, Sternberg DE, Hafstad KM, Giddings S, Landis H: Adrenergic receptor sensitivity in depression. Arch Gen Psychiat 1982; 39: 290–294.PubMedCrossRefGoogle Scholar
  15. Cooper SJ, Kelly JG, King DJ: Adrenergic receptors in depression effects of electroconvulsive therapy. Br J Psychiat 1985; 147: 23–29.CrossRefGoogle Scholar
  16. Daiguji M, Meltzer HY, Tong C, U’Prichard DC, Young M, Kravitz H: ß2adrenergic receptors in platelet membranes of depressed patients: No change in number or 3H-yohimbine affinity. Life Sci 1981; 29: 2059–2064.Google Scholar
  17. Davis BA: Biogenic Monamines and their Metabolites in the Urine, Plasma, and Cerebrospinal Fluid of Normal, Psychiatric, and Neurological Subjects. Boca Raton, FL: CRC Press, 1990, 179–312.Google Scholar
  18. Deakin JFW, Owen F, Cross AJ, Dashwood MJ: Studies on possible mechanisms of action of electroconvulsive therapy: Effects of repeated electrically induced seizures on rat brain receptors for monoamines and other neurotransmitters. Psychopharmacol 1981; 73: 345–349.CrossRefGoogle Scholar
  19. Demet EM, Habarus AE, Gwirtsman HE, Reno RM, Becker PI: Effects of desipramine on diurnal rhythms of plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) in depressed patients. Psychopharmacol Bull 1982; 18: 221–223.PubMedGoogle Scholar
  20. Demet GM, Halaris AE, Gwirtsman HE, Reno RM, Becker PI: Diurnal rhythm of 3-methoxy-4-hydroxyphenylglycol (MHPG): Relationship between plasma and urinary levels. Life Sci 1985; 37: 1731–1741.PubMedCrossRefGoogle Scholar
  21. DePaermentiez F, Cheetham SC, Crompton MR, Katona CLE, Horton RW: Lower cortical ß-adrenoceptor binding sites in post-mortem samples from depressed suicide victims. Br J Pharmacol 1989; 98: Supp., 818.Google Scholar
  22. Doyle MC, George AJ, Ravindran AV, Philpott R: Platelet a2-adrenoreceptor binding in elderly depressed patients. Am J Psychiat 1985; 142: 12.Google Scholar
  23. Ebstein R, Lerer B, Shapira B, Shenesh Z, Moscouch DG, Kindler S: Cyclic AMP second messenger signal amplification in depression. Br J Psychiat 1988; 152: 665–669.CrossRefGoogle Scholar
  24. Ernsberger P, Meeley MP, Mann JJ, Reis DJ: Clonidine binds to imidazole binding sites as well as a2-adrenoceptors in the ventrolateral medulla. Eur Pharmacol 1987; 134: 1–13.CrossRefGoogle Scholar
  25. Esler M, Turbott JT, Schwartz R, Leonard P, Bobik A, Skeurs H, Jackman G: The peripheral kinetics of norepinephrine in depressive illness. Arch Gen Psychiat 1982; 39: 295–300.PubMedCrossRefGoogle Scholar
  26. Extein I, Tallman J, Smith CC, Goodwin FK: Changes in lymphocyte beta-adren- ergic receptors in depression and mania. Psychiat Res 1979; 1: 191–197.CrossRefGoogle Scholar
  27. Fawcett JA, Maas JW, Dekirmenjian H: Depression and MHPG excretion: Response to dextroamphetamines and tricycle antidepressants. Arch Gen Psychiat 1972; 26: 246–251.PubMedCrossRefGoogle Scholar
  28. Filser JG, Spira J, Fischer M, Gattaz WF, Müller WE: The evolution of 4-hydroxy3-methoxy-phenylglycol sulfate as a possible marker of control norepinephrine turnover studies in healthy volunteers and depressed patients. J Psychiat Res 1988; 22: 171–181.PubMedCrossRefGoogle Scholar
  29. Garcia-Sevilla JA, Garcia-Vallejo P, Guimon J: Enhanced a2-adrenoceptor-mediated platelet aggregation in patients with major depressive disorder. Eur J Pharmacol 1983; 94: 359–360.PubMedCrossRefGoogle Scholar
  30. Garcia-Sevilla JA, Guimon J, Garcia-Vallejo P, Fuster MJ: Biochemical and functional evidence of supersensitive platelet a2-adrenoreceptors in major affective disorder: Effect of long-term carbonate treatment. Arch Gen Psychiat 1986; 43: 51–57.PubMedCrossRefGoogle Scholar
  31. Garcia-Sevilla JA, Hollingsworth PJ, Smith CB: Alpha2-adrenoceptors on human platelets: Selective labelling by [3H] clonidine and [3H]yohimbine and competitive inhibition by antidepressant drugs. Eur J Pharmacol 1981; 74: 329–341.PubMedCrossRefGoogle Scholar
  32. Garcia-Sevilla JA, Padro D, Giralt MT, Guimon J, Areso P: a2-adrenoceptormediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Effect of long-term antidepressant drug treatment. Arch Gen Psychiat 1990; 47: 125–132.PubMedCrossRefGoogle Scholar
  33. Georgotas A, Schweitzer J, McCue RE, Armour M, Friedhoff AJ: Clinical and treatment effects on 3H-clonidine and 3H-imipramine binding in elderly depressed patients. Life Sci 1987; 40 2137–2143.PubMedCrossRefGoogle Scholar
  34. Goldstein DS, Eisenhofer G, Stull R, Folio CJ, Keiser HR, Kopin IJ: Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J Clin Investigat 1988; 81: 213–220.CrossRefGoogle Scholar
  35. Goldstein DS, Zimlichman R, Kelly GD, Stull R, Backer JD, Keiser HR: Effect of ganglion blockade on cerebrospinal fluid norepinephrine. J Neurochem 1987; 49: 1484–1490.PubMedCrossRefGoogle Scholar
  36. Goodwin FK, Cowdry RW, Webster MH: Predictors of drug response in the affective disorders: Toward an integrated approach. In M.A. Lipton, A.D. Maschio, & K.F. Killam (Eds.), Psychopharmacology: A Generation of Progress. New York: Raven Press, 1978, 1277–1288.Google Scholar
  37. Goodwin FK, Jamison KR: Biochemical and pharmacologic studies. In: Goodwin FK, Jamison KR (Eds.), Manic Depressive Illness,New York: Oxford, 1990, 416–502. University Press.Google Scholar
  38. Halaris AE, Demet EM: Parameters affecting norepinephrine metabolism in healthy and depressed populations (Abstract). Proceedings of the 20th Annual Meeting of the American College of Neuropsychopharmacology, 1981.Google Scholar
  39. Halper JP, Brown RP, Sweeney JA, Kocsis JH, Peters A, Mann JJ: Blunted betaadrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Isoproterenol dose-response studies. Arch Gen Psychiat 1988; 45: 241–244.PubMedCrossRefGoogle Scholar
  40. Healy D, Carney PA, Leonard BE: Monoamine-related markers of depression: Changes following treatment. J Psychiat Res 1983; 17: 251–260.CrossRefGoogle Scholar
  41. Healy D, Halloran AO, Carney PA, Leonard BE: Peripheral adrenoreceptors and serotonin receptors in depression: Changes associated with response to treatment with trazadone on amitriptyline. J Affect Disord 1985; 9: 285–296.PubMedCrossRefGoogle Scholar
  42. Hollister LE, Davis KL, Berger PA: Subtypes of depression based on excretion of MHPG and response to nortriptyline. Arch Gen Psychiat 1980; 37: 1107–1110.PubMedCrossRefGoogle Scholar
  43. Horton RW, Katona CLE, Theodorou AE, Hale AS, Davies SL, Tunnicliffe C, Yamaguchi Y, Paykel ES, Kelly JS: Platelet radioligand binding and neuroendocrine challenge tests in depression. Antidepressant and receptor function. Ciba Found Sym 1988; 123: 84–105.Google Scholar
  44. Janicak PG, Davis JM, Chan C, Altman E, Hedeker D: Failure of urinary MHPG levels to predict treatment response in patients with unipolar depression. Am J Psychiat 1986; 143: 1398–1402.PubMedGoogle Scholar
  45. Kafka MS, Nurnberger JI, Siever LJ, Targum S, Uhde TW, Gershon ES: Alpha2adrenergic receptor function in patients with unipolar and bipolar affective disorder. J Affect Disord 1986; 10: 163–169.Google Scholar
  46. Kafka MS, Paul SM: Platelet a2-adrenergic receptors in depression. Arch Gen Psychiat 1986; 43: 91–95.PubMedCrossRefGoogle Scholar
  47. Katona CLE, Theodorou AE, Davies SL, Hale AS, Kerry SM, Horton RW, Kelly JS, Paykel ES: [3H]yohimbine binding to platelet a2-adrenoreceptors in depression. J Affect Disord 1989; 17: 219–228.PubMedCrossRefGoogle Scholar
  48. Klysner R, Geisler A, Rosenberg R: Enhanced histamine and ß-adrenoreceptor mediated cyclic AMP formation in leukocytes from patients with endogenous depression. J Affect Disord 1987; 13: 227–232.PubMedCrossRefGoogle Scholar
  49. Kopin IJ: Avenues of investigation for the role of catecholamines in anxiety. Psychopathol 1984; 17: Suppl. 1, 83–97.Google Scholar
  50. Kopin IJ: Catecholamine metabolism: Basic aspects and clinical significance. Pharmacol Rev. 1985; 37: 333–364.PubMedGoogle Scholar
  51. Lackmann JF, Maas JW, Heninger GR: Covariance of plasma free 3-methoxy-4hydroxyphenethylene glycol and diastolic blood pressure. Eur J Pharmacol 70: 111–120.Google Scholar
  52. Lackmann JF, Maas JW, Redmond Jr DE, Heninger GR: Effects of oral clonidine on plasma-3-methoxy-4-hydroxy phenethyleneglycol (MHPG) in man: Preliminary report. Life Sci 1980; 26: 2179–2185.CrossRefGoogle Scholar
  53. Lenox RH, Ellis JE, Van Riper DA, Ehrlich YH, Peyser JM, Shipley JE, Weaver LA: Platelet a2-adrenergic receptor activity in clinical studies of depression. In Usdin E. (Ed.), Frontiers in Neuropsychiatric Research, London: Macmillan Press, 1983, 331–355.Google Scholar
  54. Linnoila M, Guthrie S, Lane EA, Karoum F, Rudorfer M, Potter WZ: Clinical studies on norepinephrine metabolism: How to interpret the number. Psychiat Res 1986; 17: 229–239.CrossRefGoogle Scholar
  55. Linsell CR, Lightman SL, Mullen PE, Brown MS, Causin RC: Cicadian rhythms of epinephrine and norepinephrine in man. J Clin Endocrinol Metab 1985; 60: 1210–1215.PubMedCrossRefGoogle Scholar
  56. Ludwig J, Gerhardt T, Halbrügge T, Walter J, Graefe KH: Plasma concentrations of noradrenaline and 3, 4 dihydroxyphenylglycol under conditions of enhanced sympathetic activity. Eur J Clin Pharmacol 1988; 35: 261–267.PubMedCrossRefGoogle Scholar
  57. Maglazzi JR, Gietzen D, Maddock RJ, Haack D, Doran AR, Goodman T, Weiler PG: Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls. Biol Psychiat 1989; 26: 15–25.CrossRefGoogle Scholar
  58. Mann JJ, Brown RP, Halper JP, Sweeney JA, Kocsis JH, Stocker PE, Bilezikian JP: Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. New Eng J Med 1985; 313: 715–720.PubMedCrossRefGoogle Scholar
  59. Mann JJ, Mahler JC, Winer RJ, Halper JP, Brown RP, Johnson KS, Kocsis JH, Chen JS: Normalization of blunted lymphocyte N-adrenergic responsivity in melancholic inpatients by a course of electroconvulsive therapy. Arch Gen Psychiat 1990; 47: 461–464.PubMedCrossRefGoogle Scholar
  60. Mann JJ, Stanley M, McBride PA, McEwen BS: Increased serotonin2 and ß-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiat 1986; 43: 954–969.PubMedCrossRefGoogle Scholar
  61. Maas JW, Fawcett JA, Pekirmenjian H: Catecholamine metabolism, depressive illness, and drug response. Arch Gen Psychiat 1972; 26: 252–262.PubMedCrossRefGoogle Scholar
  62. Maas JW, Kocsis JH, Bowden CL, Davis JM, Redmond DE, Hanen I, Robins E: Pretreatment on neurotransmitter metabolites and response to imipramine or amitriptyline treatment. Psychol Med 1982; 12: 37–43.PubMedCrossRefGoogle Scholar
  63. Meeley MP, Ernsberger PR, Granata AR, Reis DJ: An endogenous clonidinedisplacing substance from bovine brain: Receptor binding and hypotensive actions in the ventrolateral medulla. Life Sci 1986; 38: 1119–1126.PubMedCrossRefGoogle Scholar
  64. Michel MC, Regan JW, Gerhardt MA, Neubig RR, Insel PA, Motulsky HJ: Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha2adrenergic receptors. Mol Pharmacol 1990; 37: 65–68.PubMedGoogle Scholar
  65. Mishra N, Hamilton CA, Jones CR, Leslie C, Reid JL: Alpha adrenoceptor changes after estrogen treatment in platelets and other tissues in female rabbits. Clin Sci 1985; 69: 235–238.PubMedGoogle Scholar
  66. Mishra N, Hamilton CA, Jones CR, Reid JL: The effects of sexual maturation on alpha adrenoceptors in female rabbits. Eur J Pharmacol 1985; 112: 243–247.PubMedCrossRefGoogle Scholar
  67. Muscettola G, Potter WZ, Pickar D, Goodwin F: Urinary 3-methoxy-4-hydroxy-phenylglycol and major affective disorders. Arch Gen Psychiat 1984; 41: 337–342. Nutt DJ: Altered central alpha2-adrenoreceptor sensitivity in panic disorder. Arch Gen Psychiat 1989; 46: 165–169.CrossRefGoogle Scholar
  68. Pandey GN, Davis JM: Leucocyte beta-adrenergic receptors: A marker for central beta-adrenergic receptor function in depression. Clin Neuropharmacol 1986; 9: Suppl. 14: 353–355.Google Scholar
  69. Pandey GN, Dysken MW, Garver DL, Davis JM: Beta-adrenergic receptor function in affective illness. Am J Psychiat 1979: 136: 675–678. Google Scholar
  70. Pandey GN, Jamcak P, Davis JM: Studies of beta-adrenergic receptors in leukocytes of patients with affective illness and effects of antidepressant drugs. Psychopharmacol Bull 1985; 21: 603.PubMedGoogle Scholar
  71. Pandey GN, Janicak PG, Javaid JI, Davis JM: Increased 3H-clonidine binding in the platelets of patients with depressive and schizophrenic disorders. Psychiat Res 1989; 28: 73–88.CrossRefGoogle Scholar
  72. Pickar D, Sweeney DR, Maas JW, Heninger R: Primary affective disorder, clinical state change and MHPG excretion. A Longitudinal study. Arch Gen Psychiat 1978; 35: 1378–1383.PubMedCrossRefGoogle Scholar
  73. Piletz JE, Schubert DSP, Halaris A: Evaluation of studies on platelet alpha2 adrenoreceptors in depressive illness. Life Sci 1986; 39: 1589–1616. Google Scholar
  74. Post RM, Rubinow DR, Uhde TW, Roy-Byrne PP, Linnoila M, Rosoff A, Cowdry R: Dysphoric mania. Arch Gen Psychiat 1989; 46: 353–358. Google Scholar
  75. Post RM, Jimerson DC, Ballenger JC, Lake CR, Uhde TW, Goodwin FK: In: Post RM, Ballenger JC (Eds.), Neurology of Mood Disorders, Baltimore: Williams and Wilkens, 1984, 539–553.Google Scholar
  76. Potter WZ, Linnoila M: Biochemical classifications of diagnostic subgroups and D-type scores. Arch Gen Psychiat 1989; 46: 269–271. Google Scholar
  77. Potter WZ, Rudorfer MV, Linnoila M: Effects of antidepressants in norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Prog Catecholamine Res C: Clin Asp 1988; 301–306.Google Scholar
  78. Roberts JM, Goldfien RD, Tsuchiya AM, Goldfien A, Insel PA: Estrogen treatment decreases alpha adrenergic binding sites on rabbit platelets. Endocrinol 1979; 104: 722–728.CrossRefGoogle Scholar
  79. Rosenbaum AH, Schatzberg AF, Maruter T, Orsulak PJ, Cole JO, Grab EL, Schildkraut JJ: MHPG as a predictor of antidepressant responses to imipramine and maprotiline. Am J Psychiat 1980; 137: 1090–1092.PubMedGoogle Scholar
  80. Roy A, Jimerson DC, Pickar D: Plasma MHPG in depressive disorders and relationship to the dexamethasone suppression test. Am J Psychiat 1986; 143 (7): 846–851.PubMedGoogle Scholar
  81. Rudorfer MV, Ross RS, Linnoila M, Sherer MA, Potter WZ: Exaggerated orthostatic responsivity of plasma norepinephrine in depression. Arch Gen Psychiat 42: 1186–1192.Google Scholar
  82. Sacchetti E, Conte G, Pennati A, Vita A, Alciati A, Cazzullo CL: Platelet a2adrenoceptors in major depression: Relationship with urinary 4-hydroxy-3methoxyphenylglycol and age at onset. J Psychiat Res 1985; 19: 579–586.PubMedCrossRefGoogle Scholar
  83. Sack DA, James SP, Doran AR, Sherer MA, Linnoila M, Wehr TA: The diurnal variations in plasma homovanillic acid level persists but the variation in 3-methoxy-4-hydroxyphenylglycol level is abolished under constant conditions. Arch Gen Psychiat 1988: 45: 162–166.PubMedCrossRefGoogle Scholar
  84. Sarai K, Nakahara T, Kanagana K, Yoshihara S: Lymphocyte beta-adrenergic receptor function in affective disorders. Adv Biosci 1982; 40: 161–165. Google Scholar
  85. Schatzberg AF, Orsulak PJ, Rosenbaum AH, Kroger ER, Schildkraut JJ, Cole JO: Catecholamine measures for diagnosis and treatment of patients with depressive disorders. J Clin Psychiat 1980; 41: 35–39. Google Scholar
  86. Schatzberg AP, Samson JA, Bloomingdale KC, Orsulak PJ, Gerson B, Kizuka PP, Cole JO, Schildkraut JJ: Toward a biochemical classification of depressive disorders: Urinary catecholamines, their metabolites and D-type scores in subgroups of depressive disorders. Arch Gen Psychiat 1989; 46: 260–268.PubMedCrossRefGoogle Scholar
  87. Schildkraut JJ, Orsulak PJ, Schatzberg AF, Cole JO, Rosenbaum AH: Biochemical discrimination of subgroups of depression disorders based on differences in catecholamine metabolism. In: Usdin E, Hamin I (Eds.), Biological Markers in Psychiatry and Neurology, New York: I’ergamon Press, 1978, 23–33.Google Scholar
  88. Schildkraut JJ, Orsulak PJ, Schatzberg AF, Gudeman JE, Cole JO, Rohde WA, LaBrie RA: Toward a biochemical classification of depressive disorders: Differences in urinary excretion of MHPG and other catecholamine metabolites in clinically defined subtypes of depression. Arch Gen Psychiat 1978; 35: 1427–1433.PubMedCrossRefGoogle Scholar
  89. Siever LJ, Insel TR, Jimerson DC, Lake CR, Uhde TW, Aloi J, Murphy DL: Growth hormone response to clonidine in obsessive-compulsive patients. Br J Psychiat 1983; 142: 184–187. Siever LJ, Kafka MS, Targum S, Lake CR: Platelet alpha-adrenergic binding and biochmeical esponsiveness in depressed patients and controls. Psychiat Res 1984; 11: 287–302.CrossRefGoogle Scholar
  90. Siever LJ, Uhde TW, Jimerson DC, Lake CR, Silverman ER, Post ER, Murphy DL: Differential inhibitory noradrenergic responses to clonidine in 25 depressed patients and 25 normal control subjects. Am J Psychiat 1984; 141: 733.PubMedGoogle Scholar
  91. Siever LJ, Uhde TW, Jimerson DC, Post RM, Lake CR, Murphy DL: Plasma cortisol responses to clonidine in depressed patients and controls. Evidence for possible alteration in noradrenergic-neuroendocrine relationships. Arch Gen Psychiat 1986; 41: 63–68.CrossRefGoogle Scholar
  92. Siever LJ: Role of noradrenergic mechanisms in the etiology of the affective disorders. In: Meltzer HY (Ed.), Psychopharmacology: The Third Generation of Progress. New York: Raven Press, 1987, 493–504.Google Scholar
  93. Siever LJ, Uhde TW, Silberman EK, Jimerson DC, Aloi JA, Post RM, Murphy DL: Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Psychiat Res 1982; 6: 171–183.CrossRefGoogle Scholar
  94. Smith CB, Hollingsworth PJ, Garcia-Sevilla JA, Zis AP: Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy. Prog Neuropsychopharmacol Biol Psychiat 1983; 7: 241–247.CrossRefGoogle Scholar
  95. Stahl SM, Lemoine PM, Ciaranello RD, Berger PA: Platelet alpha2-adrenergic receptor sensitivity in major depressive disorder. Psychiat Res 1983; 10: 157–164.Google Scholar
  96. Sulser F, Vetulani J, Mobley PL: Mode of action of antidepressant drugs. Biochem Pharmacol 1978; 27: 257–271.Google Scholar
  97. Uhde TW, Vittone BJ, Siever LJ, Kaye WH, Post RM: Blunted growth hormone response to clonidine in panic disorder patients. Biol Psychiat 1986; 21: 1081–1085.PubMedCrossRefGoogle Scholar
  98. Veith RC, Halter JB, Murburg MM, Barnes RF, Villacre E, Bachus FI: Increased plasma NE appearance rate in dexamethasone resistant depression. Fourth World Congress of Biological Psychiatry, 1985, 186.Google Scholar
  99. Wang, XL, Brodde O-E: Identification of a homogeneous class of ß2 adrenoceptors in human platelets by (125I-iodopindolol binding. J Cyclic Nucleotide Protein Phosphorous Res 1985; 10: 439–450.Google Scholar
  100. Wehr TA, Muscettola G, Goodwin FK: Urinary 3-methoxy-4-hydroxyphenylglycol circadian rhythms. Arch Gen Psychiat 1980; 37: 257–263.PubMedCrossRefGoogle Scholar
  101. Werstiuk ES, Steiner M, Burns T: Studies on leukocyte ß-adrenergic receptors in depression: A critical appraisal. Life Sci 1990; 47: 85–105.PubMedCrossRefGoogle Scholar
  102. Wolfe N, Cohen BM, Gelenberg AJ: Alpha2-adrenergic receptors in platelet membranes of depressed patients: Increased affinity for 3H-yohimbine. Psychiat Res 1986; 20: 107–116.CrossRefGoogle Scholar
  103. Wolfe N, Gelenberg AJ, Lydiard RB: Alpha2-adrenergic receptor sensitivity in depressed patients: Relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension. Biol Psychiat 1989; 25: 382–392.Google Scholar
  104. Wright AF, Crichton DN, Loudon JB, Morton JEN, Steel CM: f3-adrenoreceptor binding defects in cell lines from families with manic-depressive disorder. Ann Human Genet 1984; 48: 210–214.CrossRefGoogle Scholar
  105. Ziegler MG, Milano AJ, Hull E: In Lake R, Ziegler MG (Eds.) The Catecholamines in Psychiatric and Neurological Disorders. Boston: Butterworth Publishers, 1985, 37–53.Google Scholar
  106. Zohar J, Bannet J, Drummer D, Fisch R, Epstein RP, Belmaker RH: The responses of lymphocyte beta-adrenergic receptors to chronic propranolol treatment in depressed patients, schizophrenic patients, and normal controls. Biol Psychiat 1983; 18: 553–560.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • William Z. Potter
    • 1
  • Fred Grossman
    • 1
  • Matthew V. Rudorfer
    • 1
  1. 1.Section on Clinical Pharmacology, Experimental Therapeutic BranchNational Institute of Mental HealthBethesdaUSA

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