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T-Cell Line Interactions with Brain Endothelial Monolayers

  • P. M. G. Munro
  • L. A. McLaughlin-Borlace
  • G. Pryce
  • N. L. Occleston
  • J. Greenwood
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Summary

In this communication we outline and illustrate some of the many structural and functional similarities that in vitro lymphocyte-endothelial interactions share with inflammation in vivo. Data presented here suggests, but does not prove, lymphocyte diapedesis in vitro to be a parajunctional process also involving enzymatic destruction of the endothelial basement membrane.

Keywords

Basement Membrane Endothelial Cell Monolayer Zymographic Analysis Experimental Autoimmune Uveoretinitis Face Section 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Dans cette communication, nous soulignons et illustrons les similarités structurales et fonctionnelles entre les interactions endothelium-lymphocytes in vitro et l’inflammation in vivo. Les données présentées ici suggèrent mais ne prouvent pas que la diapédèse des lymphocytes in vitro est un processus impliquant la destruction enzymatique de la membrane basale endothéliale.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • P. M. G. Munro
    • 1
  • L. A. McLaughlin-Borlace
    • 1
  • G. Pryce
    • 1
  • N. L. Occleston
    • 2
  • J. Greenwood
    • 1
  1. 1.Department of Clinical ScienceUniversity College LondonLondonUK
  2. 2.Department of Pathology Institute of OphthalmologyUniversity College LondonLondonUK

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