Summary
The integrity of the blood-brain barrier may severely restrict the passage of drugs intended for cells within the central nervous system. These experiments were designed to show whether one particular drug used for the treatment of gliomas, boronophenylalanine (BPA), is affected by the state of the BBB.
The results show that the degree of BBB disruption does not influence the amount of BPA accumulating in normal brain tissue.
Résumé
L’absence de perméabilité membranaire de la barrière hémato-encéphalique (BHE) peut restreindre gravement le passage de dérivés thérapeutiques destinés à traiter les cellules contenues dans le SNC. Cette étude a pour but de vérifier si l’action d’un dérivé particulier, utilisé pour le traitement des gliomes, la boronophénylalanine (BPA), est affectée par l’état de la BHE. Les résultats montrent que le degré de rupture de la BHE ne modifie pas la quantité de BPA accumulée dans les tissus normaux du cerveau.
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© 1996 Springer Science+Business Media New York
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Patel, H., Hopewell, J.W. (1996). The Permeability of Boronophenylalanine. In: Couraud, PO., Scherman, D. (eds) Biology and Physiology of the Blood-Brain Barrier. Advances in Behavioral Biology, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9489-2_27
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DOI: https://doi.org/10.1007/978-1-4757-9489-2_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9491-5
Online ISBN: 978-1-4757-9489-2
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