Prospects for Neuroprotective Gene Therapy for Neurodegenerative Diseases
Neurodegenerative diseases are still, except for a few of them like Parkinson’s disease, out of reach of available therapeutics. Several breakthroughs in the past ten years have, however, opened new potential ways that are actively explored in a large number of laboratories. Two of these major advances that could be of therapeutic value are the discovery of several families of substances that are able to exert neuroprotective effects on the one hand, development of gene engineering techniques on the other hand. In our laboratory, a series of studies are ongoing to design ways, using these engineering techniques, to create biological minipumps able to secrete neuroprotective agents into the brain.
KeywordsAmyotrophic Lateral Sclerosis Adenovirus Vector Embryonal Carcinoma Neuroprotective Agent Exogenous Gene
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