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Blood-Retina Barrier Properties of the Pecten Oculi of the Chicken

  • Holger Gerhardt
  • Stefan Liebner
  • Hartwig Wolburg
Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Abstract

The site of the blood-brain or blood-retina barrier is the tight junction between endothelial and pigment epithelial cells, respectively. Considerable effort has been provided for understanding the nature of tight junctions and their regulation. It has become clear that morphology and physiology of blood brain barrier endothelium heavily alters if cultured in vitro(1) and that, as a result, blood brain barrier properties are highly dependent on the brain microenvironment. Therefore, we looked for a new model-system, preferably posessing the combined validity of the in vivo situation and the simplicity of an in vitro system. We found it in the pecten oculi of the avian eye, which is a pleated vascular structure, protruding from the optic nerve head into the vitreous (for a review, see 2). Although the pecten is well-known for a long time, its function is still a matter of controversal speculation. Regulation of the pH-value, of the temperature and of the inner bulb pressure of the eye, as well as support in movement detection and nutrition of the retina have been considered.

Keywords

Tight Junction Retinal Pigment Epithelium Barrier Property Optic Nerve Head Pigment Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Holger Gerhardt
  • Stefan Liebner
  • Hartwig Wolburg

There are no affiliations available

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