The Possible Roles of Astrocytes in Energy Metabolism of the Brain
In the brain astrocytes are situated in a key position between the microvessels and the other cell types, neurons and oligodendrocytes. If one considers the narrow extracellular space between the brain cells, the conclusion appears inescapable that the nutrients of the brain, such as the quantitatively most important substrates for the generation of energy, glucose and oxygen, must cross the astrocytes to reach their metabolic destination in the neurons and oligodendrocytes. This location also could be the prerequisite for playing a pivotal role in controlling energy metabolism of the brain. However, in saying this one has to add immediately that little is known on such an -anthropomorphically seen — attractive function of astrocytes.
KeywordsGlial Fibrillary Acidic Protein Malic Enzyme Glycogen Phosphorylase Astroglial Cell Glucosyl Residue
Unable to display preview. Download preview PDF.
- Dringen R. and Hamprecht B., 1990, Modulation of glycogen content in astrocytes. Biol. Chem. Hoppe-Seyler 371: 780.Google Scholar
- Dringen R. and Hamprecht B., 1991, Modulation of astrocytic glycogen by hexoses. J. Neurochem. 57, Suppl., S127D.Google Scholar
- Dringen R. and Hamprecht B., 1992b, Investigation on the function of glycogen in astrocytes. Biol. Chem. Hoppe-Seyler, 373: 951.Google Scholar
- Dringen R. and Hamprecht B., 1992c, Inhibition by 2-deoxyglucose and 1,5-gluconolactone of glycogen mobilization in astroglia-rich primary cultures. J. Neurochem.,in press.Google Scholar
- Geiger A., 1958, Correlation of brain metabolism and function by the use of a brain perfusion method in situ. Physiol. Revs., 38: 1.Google Scholar
- Kurz G., Wiesinger H., and Hamprecht B., 1992, Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures. J. Neurochem.,in press.Google Scholar
- Lamer J., 1990, Insulin and the stimulation of glycogen synthesis. The road from glycogen structure to glycogen synthase to cyclic AMP-dependent protein kinase to insulin mediators. Adv. Enzymol., 63: 173.Google Scholar
- Tsacopoulos M., Coles J.A., and Van de Werve G., 1987, The supply of metabolic substrate from glia to photoreceptors in the retina of the honeybee drone. J. Physiol. 82: 279.Google Scholar