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Inter-Cellular Signalling by Nitric Oxide

  • John Garthwaite
  • Eric Southam
  • Richard Morris
Part of the Altschul Symposia Series book series (ALSS, volume 2)

Abstract

It has been known for many years that excitation in the central nervous system is associated with marked elevations in the levels of the second messenger, cyclic GMP (cGMP) (Drummond, 1983). These are now known to be mediated through the release of the novel messenger molecule, nitric oxide (NO), which functions as a powerful activator of the soluble form of the cGMP synthesising enzyme, guanylate cyclase (Garthwaite, 1991). NO has a number of properties which set it apart from conventional signalling molecules, not least of which is its ability to diffuse readily across membranes and so act on cellular elements located some distance from the site of its formation. As discussed below, the targets for neuronally-derived NO include other neurons and neighbouring glial cells.

Keywords

Nitric Oxide NMDA Receptor Dorsal Root Ganglion Satellite Cell Excitatory Amino Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • John Garthwaite
    • 1
  • Eric Southam
    • 1
  • Richard Morris
    • 2
  1. 1.Department of PhysiologyUniversity of LiverpoolLiverpoolUK
  2. 2.Preclinical Veterinary ScienceUniversity of LiverpoolLiverpoolUK

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