Paracrine and Autocrine Signalling in Regulation of Microglia Survival

  • Sergey Fedoroff
  • Chunhai Hao
  • Ijaz Ahmed
  • Larry J. Guilbert
Part of the Altschul Symposia Series book series (ALSS, volume 2)


Microglia have been known as a cellular entity of the CNS for about 73 years (del Rio Hortega, 1919 a,b,c,d). Their morphology, based on silver carbonate stains (del Rio Hortega, 1932) and more recently, on immunocytochemistry (Perry and Gordon, 1991), has been described; their distribution has been determined by immunocytochemistry (Lawson et al., 1990); and their response to pathological changes has been examined by classical histological methods, electron microscopy and by immunocytochemistry (Dickson et al., 1991; Polak et al., 1982, Streit and Kreutzberg, 1988). Their function, however, other than that denoted by the term “brain macrophages”, is only now being investigated. Microglia are components of the neuron-glia and the neuroimmune networks (Benveniste, 1988; Goetzl and Spector, 1980). They communicate by means of a number of signaling molecules. Because of the complexity of the networks and multiple signalling, study of microglia function in situ is difficult. Recently, in several laboratories, microglia and brain macrophages have been isolated and grown in tissue culture (reviewed by Hao et al., 1991), and under these conditions the secretion of trophic factors and response to various ligands can be evaluated and cell interactions postulated.


Colony Stimulate Factor Mononuclear Phagocyte Microglia Culture Murine Peritoneal Macrophage Bone Marrow Macrophage 


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sergey Fedoroff
    • 1
  • Chunhai Hao
    • 1
  • Ijaz Ahmed
    • 1
  • Larry J. Guilbert
    • 2
  1. 1.Department of Anatomy, College of MedicineUniversity of SaskatchewanSaskatoonCanada
  2. 2.Department of ImmunologyUniversity of AlbertaEdmontonCanada

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