The Role of 5-HT1A Receptors in Development and Adult Plasticity of the Serotonergic System
Astroglial cells play important roles in determining brain structure and function throughout life; the astrocyte must be able to change its function in order to play the appropriate age-dependent role. One such role is the production of neuronal growth factors. During development, the astrocyte may produce and release large amounts of growth factors, while in mature states, the astrocytes may produce and release very low levels, just enough to aid in synaptic turnover. In responding to a lesion of the neuron, the astrocyte may again greatly increase its growth factor output.
KeywordsDown Syndrome Serotonergic Neuron Neurotransmitter Receptor Astroglial Cell Trophic Activity
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