How Does Thrombin Cause Neurite Retraction ?
Recent studies have established that thrombin modulates neuronal and glial cytoarchitecture. Thrombin antagonizes the neurite promoting activity of its inhibitor glia-derived nexin (Monard et al., 1983) and induces neurite retraction in mouse NB2a and human SK-N-SH neuroblastoma cells (Gurwitz and Cunningham, 1988; Grand et al., 1989), cultured human cerebellar and hippocampal neurons, and in AD12 HER10 cells of neuroepithelial origin (Grand et al., 1989; Grabham et al., 1991). Mouse dorsal root ganglion neurons grow shorter neuntes in the presence of thrombin (Hawkins and Seeds, 1986) and neuntes turn away from a source of thrombin placed in the culture system (Hawkins and Seeds, 1989). Thrombin has also been reported to reverse the cyclic AMP-induced stellation of cultured astrocytes and glioma cells (Cavanaugh et al., 1990, Nelson and Siman, 1990; Tas and Koschel, 1990).
KeywordsNeuroblastoma Cell Neurite Outgrowth Protein Kinase Inhibitor Neurite Length Thrombin Receptor
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