Vale and his colleagues (1989) devised a method of attaching single dynein molecules to a substrate and observing the motion of microtubules. In one series of experiments they inhibited the enzymatic activity of the dynein with vanadate. By fitting a Gaussian to this data, they obtained the diffusion constants shown in Table 1. However, according to the theoretical formulas for longitudinal and transverse diffusion of a cylinder these diffusion constants should be much larger. (The longitudinal and transverse diffusion coefficients are given by the following expressions: D L = kTln(2h/r)/2πηL and D T = kTln(2h/r)/4πηL (Brennen and Winet, 1977)). This discrepancy suggests two models for the interaction.
KeywordsVanadate Librium Abate Peaked Vale
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