Physics from Proteins

  • Hans Frauenfelder
  • Kelvin Chu
  • Robert Philipp
Part of the NATO ASI Series book series (NSSB, volume 263)


The title of the workshop, “Biologically Inspired Physics” also heralds the goal of this contribution: Can we learn “new” physics by studying biological systems? In biophysics, physical tools are used to explore the structure and function of biological systems, ranging from biomolecules to the brain.


Rate Coefficient Energy Landscape Relaxation Function Effective Barrier Height Conformational Substate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Agmon, N., Hopfield, J. J. (1983) J. Chem. Phys. 79, 2042–2053.ADSCrossRefGoogle Scholar
  2. 2.
    Ansari, A., Berendzen, J., Bowne, S. F., Frauenfelder, H., Iben, I. E. T., Sauke, T. B., Shyamsunder, E., Young, R. D. (1985) Proc. Natl. Acad. Sci. USA 82, 5000–5004.ADSCrossRefGoogle Scholar
  3. 3.
    Ansari, A., Berendzen, J., Braunstein, D., Cowen, B. R., Frauenfelder, H., Hong, M. K., Iben, I. E. T., Johnson J. B., Ormos, P., Sauke, T. B., Scholl, R., Schulte, A., Steinbach, P. J., Vittitow, J., Young, R. D. (1987) Biophys. Chem. 26, 337–355.CrossRefGoogle Scholar
  4. 4.
    Austin, R. H., Beeson, K. W., Eisenstein, L., Frauenfelder, H., Gunsalus, I. C. (1975) Biochemistry 17, 5355–5373.CrossRefGoogle Scholar
  5. 5.
    Bässler, H. (1987) Phys. Rev. Lett. 58, 767–770.ADSCrossRefGoogle Scholar
  6. 6.
    Berendzen, J. R., Braunstein, D. (1990) Proc. Natl. Acad. USA 87, 1–5.ADSCrossRefGoogle Scholar
  7. 7.
    Brawer, S. A. (1984) J. Chem. Phys. f 81(2), 954–975.ADSCrossRefGoogle Scholar
  8. 8.
    Charles L. Brooks III, Martin Karplus, B. Montgomery Pettit, Proteins: A Theoretical Perspective of Dynamics, Structure and Thermodynamics, Wiley, New York, 1988.Google Scholar
  9. 9.
    Bryngelson, J., Wolynes, P. G. (1989) J. Phys. Chem. 93, 6902–6915.CrossRefGoogle Scholar
  10. 10.
    Callen, H. B., Welton, T. A., Phys. Rev., 88, 34.Google Scholar
  11. 11.
    Chothia, C., (1984) Ann. Rev. Biochem. 53, 537–572.CrossRefGoogle Scholar
  12. 12.
    R. E. Dickerson and I. Geis, The Structure and Action of Proteins, Benjamin-Cummings, Menlo Park, 1969.Google Scholar
  13. 13.
    Einstein, A., (1905) A. Physik 17, 549.zbMATHCrossRefGoogle Scholar
  14. 14.
    Frauenfelder, H. (1985) Ligand binding and protein dynamics, in Structure and Motion: Membranes, Nucleic Acids and Proteins, E. Clementi, G. Corongiu, M. H. Sarma, and R. H. Sarma, ed., Adenine Press, Guilderland, NY, 205–217.Google Scholar
  15. 15.
    Frauenfelder, H., Alberding, N. A., Ansari, A., Braunstein, D., Cowen, B. R., Hong, M. K., Iben, I. E. T., Johnson, J. B., Luck, S., Marden, M. C., Mourant, J. R., Ormos, P., Reinisch, L., Scholl, R., Schulte, A., Shyamsunder, E., Sorensen, L. B., Steinbach, P. J., Xie, A-H., Young, R. D., Yue, K. T. (1990) J. Phys. Chem. 94, 1024–1037.CrossRefGoogle Scholar
  16. 16.
    Frauenfelder, H., Petsko, G. A., Tsernoglou, D. (1979) Nature 280, 558–563.ADSCrossRefGoogle Scholar
  17. 17.
    Frauenfelder, H., (1984) Helv. Phys. Acta 57, 165–187.Google Scholar
  18. 18.
    Frauenfelder, H., Parak, F., Young, R. D., (1988) Ann. Rev. Biophys. Biophys. Chem. 17, 451–79.CrossRefGoogle Scholar
  19. 19.
    Frauenfelder, H., (1989) Intern. J. of Quantum Chem. XXXV, 711–715.CrossRefGoogle Scholar
  20. 20.
    Derrida, B. (1980) Phys. Rev. Lett. 45(2), 79–82.MathSciNetADSCrossRefGoogle Scholar
  21. 21.
    Doster, W., Cusack, S. and Petry, W. (1989) Nature (Lond.) 337 754–756.ADSCrossRefGoogle Scholar
  22. 22.
    R. P. Feynman, R. B. Leighton, M. Sands, The Feynman Lectures on Physics, Addison-Wesley, Menlo Park, 1963.Google Scholar
  23. 23.
    Go, N. (1983) Ann. Rev. Biophys. Bioeng., 12, 183–210.CrossRefGoogle Scholar
  24. 24.
    Gratton, E., Barbieri, B. (1986) Spectroscopy 1, 28.Google Scholar
  25. 25.
    Kuriyan, J., Wilz, S., Karplus, M., Petsko, G. (1986), J. Mol. Bio. 192 133–154.CrossRefGoogle Scholar
  26. 26.
    Kubo, R., (1966) Rep. Prog. Phys. 29, 225–284.ADSCrossRefGoogle Scholar
  27. 27.
    J. R. Lakowicz, Principles of Fluoresence Spectroscopy, Plenum, New York, 1983.CrossRefGoogle Scholar
  28. 28.
    Lindsay, C. P., Patterson, G. D. (1980) J. Chem. Phys. 73 3348.ADSCrossRefGoogle Scholar
  29. 29.
    Levitt, M., (1982) Am. Rev. Biophys. Bioeng., 11, 251–71.CrossRefGoogle Scholar
  30. 30.
    J. A. McCammon, S. C. Harver, Dynamics of Proteins and Nucleic Acids, Cambridge U. Press, Cambridge, 1987.CrossRefGoogle Scholar
  31. 31.
    Ormos, P., Braunstein, D., Frauenfelder, H., Hong, M. K., Lin, S. L., Sauke, T. B., Young, R. D. (1988) Proc. Natl. Acad. Sci. USA 85, 8492–8496.ADSCrossRefGoogle Scholar
  32. 32.
    Ormos, P., Ansari, A., Braunstein, D., Cowen, B. R., Frauenfelder, H., Hong, M. K., Iben, I. E. T., Sauke, T. B., Steinbach, P. J., Young, R. D. Biophys. J., 57, 191–199.Google Scholar
  33. 33.
    L. Peliti and V. Vulpiani, Eds., Measures of Complexity, Lecture Notes in Physics 314, Springer, New York, 1988.Google Scholar
  34. 34.
    Richert, R., Bässler, H., (1990) J. Phys.: Condens. Matter 2, 2273–2288.ADSCrossRefGoogle Scholar
  35. 35.
    Ringe, D., Petsko, G. A., (1985) Prog. Biophy Moiec. Bio., 45, 197.CrossRefGoogle Scholar
  36. 36.
    E. Schrödinger, What is Life?, Cambridge Univ. Press, Cambridge, 1967.Google Scholar
  37. 37.
    Singh, G. P., Schink, H. J., Von Löhneysen, Parak, F. and Hunklinger, S. (1984) Z. Phys. B55 23–26.ADSCrossRefGoogle Scholar
  38. 38.
    Srajer, V., Reinisch, L., Champion, P. M. (1988) J. Am. Chem. Soc. 110, 6656–6669.CrossRefGoogle Scholar
  39. 39.
    L. Stryer, Biochemistry, 3rd. ed., W. H. Freeman and Company, N. Y., 1988.Google Scholar
  40. 40.
    Williams, G., Watts, D. C. (1970) Trans. Faraday Soc. 66, 80.CrossRefGoogle Scholar
  41. 41.
    Zwanzig, R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029–2030.MathSciNetADSCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Hans Frauenfelder
    • 1
  • Kelvin Chu
    • 1
  • Robert Philipp
    • 1
  1. 1.Department of PhysicsUniversity of Illinois at Urbana-ChampaignUrbanaUSA

Personalised recommendations