Biomonitoring Workers Exposed to Arylamines
Arylamines are important intermediates in the production of plastics and polyurethanes. Employees in many factories are subjected to low level chronic exposure to a wide variety, often a mixture, of arylamines. We have developed methods to measure hemoglobin (Hb) adducts of over 30 arylamines. Using these methods we can biomonitor exposure to low levels of these chemicals. Since, in most cases the air monitoring values were below the detection limit, we have used the protein adduct levels to estimate the daily-dose, which was then compared to the daily dose which yields tumors in 50% of rodents (TD50).
KeywordsQuantitative Structure Activity Relationship Aromatic Amine Breast Implant Adduct Level Hemoglobin Adduct
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