Induction of Cytochromes P450 by Dioxins in Liver and Lung of Marmoset Monkeys (Callithrix jacchus)
The induction of specific P450 enzymes is difficult to study in man but non-human primates may provide a useful model for this purpose. At present little is known about the inducibility of P450 in the liver or extrahepatic tissues of primates. Previous investigations have shown that several P450s are inducible in the marmoset monkey (Callithrix jacchus) by compounds such as phenobarbital or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Schulz-Schalge & Webb, 1989; Schulz-Schalge et al., 1991a).
KeywordsDMSO Toluene Catalysis Cane Paracetamol
Unable to display preview. Download preview PDF.
- Schulz-Schalge T, Koch E, Golor G, Wiesmüller T, Hagenmaier HP, Neubert D (1991a) Comparison of the induction of cytochrome P450 and ethoxyresorufin O-deethylase by a single subcutaneous administration of TCDD in liver microsomes of marmoset monkeys (Callithrix jacchus) and rats. Chemosphere 23: 1933–1939CrossRefGoogle Scholar
- Schulz-Schalge T, Webb J (1989) Metabolism of some phenoxazone ethers in liver microsomes of untreated and phenobarbital-treated marmoset monkeys (Callithrix jacchus). Naunyn Schmiedebergs Arch. Pharmacol. 339: R 9Google Scholar