Induction of Cytochromes P450 by Dioxins in Liver and Lung of Marmoset Monkeys (Callithrix jacchus)

  • Thomas G. Schulz
  • Diether Neubert
  • Donald S. Davies
  • Robert J. Edwards
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Abstract

The induction of specific P450 enzymes is difficult to study in man but non-human primates may provide a useful model for this purpose. At present little is known about the inducibility of P450 in the liver or extrahepatic tissues of primates. Previous investigations have shown that several P450s are inducible in the marmoset monkey (Callithrix jacchus) by compounds such as phenobarbital or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Schulz-Schalge & Webb, 1989; Schulz-Schalge et al., 1991a).

Keywords

DMSO Toluene Catalysis Cane Paracetamol 

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References

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Thomas G. Schulz
    • 1
  • Diether Neubert
    • 2
  • Donald S. Davies
    • 1
  • Robert J. Edwards
    • 1
  1. 1.Department of Clinical PharmacologyRoyal Postgraduate Medical SchoolLondonUK
  2. 2.Institute of Toxicology and EmbryopharmacologyFree University BerlinBerlinGermany

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