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Mechanisms of Nitrosamine Bioactivation and Carcinogenesis

  • Chung S. Yang
  • Theresa J. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Abstract

It was discovered in the mid-1950s by Magee and Barnes that N-nitrosodimethylamine (NDMA) was hepatotoxic. The carcinogenicity of this compound and many other nitrosamines has since been tested by Magee, Druckrey, Preussmann, Schmähl, and others; the results of these pioneer works were summarized in two comprehensive reviews (1,2). The biochemical mechanisms of the carcinogenicity and the structure-activity relationship of the nitrosamines have since been studied by many investigators and the results have been summarized in three recent symposia (3–5). In this chapter, we will discuss the occurrence and carcinogenicity of nitrosamines, the enzyme mechanisms and the organ site of the activation, and the dose-response relationship in carcinogenesis.

Keywords

Liver Microsome Human Liver Microsome Lung Microsome Diallyl Sulfide Phenethyl Isothiocyanate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

NDMA

N-nitrosodimethylamine

NDEA

N-nitrosodiethylamine

NMOR

N-nitrosomorpholine

NDELA

N-nitrosodiethanolamine

NPYR

N-nitrosopyrrolidine

NNK

4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone

NNN

N-nitrosonornicotine

NMBzA

N’-nitrosomethylbenzylamine

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Chung S. Yang
    • 1
  • Theresa J. Smith
    • 1
  1. 1.Laboratory for Cancer Research College of PharmacyRutgers UniversityPiscatawayUSA

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