DNA Damage and Nitric Oxide

  • Larry K. Keefer
  • David A. Wink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


While there is no evidence that nitric oxide (NO) reacts directly with DNA, NO can modify the biopolymer by a variety of indirect pathways. In this review, we describe a selection of the reported mechanisms by which exposure to NO might affect the integrity of DNA, with emphasis on the biological reactive intermediates (BRIs) capable of participating in such transformations.


Nitric Oxide Ribonucleotide Reductase Tyrosyl Radical Damage Fixation Aerobic Solution 


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Larry K. Keefer
    • 1
    • 2
  • David A. Wink
    • 1
    • 2
  1. 1.Chemistry SectionLaboratory of Comparative CarcinogenesisFrederickUSA
  2. 2.National Cancer InstituteFrederick Cancer Research and Development CenterFrederickUSA

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