DNA Damage and Nitric Oxide
While there is no evidence that nitric oxide (NO) reacts directly with DNA, NO can modify the biopolymer by a variety of indirect pathways. In this review, we describe a selection of the reported mechanisms by which exposure to NO might affect the integrity of DNA, with emphasis on the biological reactive intermediates (BRIs) capable of participating in such transformations.
KeywordsNitric Oxide Ribonucleotide Reductase Tyrosyl Radical Damage Fixation Aerobic Solution
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