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Activation of Toxic Chemicals by Cytochrome P450 Enzymes

Regio- and Stereoselective Oxidation of Aflatoxin B1
  • F. Peter Guengerich
  • Yune-Fang Ueng
  • Bok-Ryang Kim
  • Sophie Langouet
  • Brian Coles
  • Rajkumar S. Iyer
  • Ricarda Thier
  • Thomas M. Harris
  • Tsutomu Shimada
  • Hiroshi Yamazaki
  • Brian Ketterer
  • Andre Guillouzo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Abstract

Cytochrome P450 (P450) enzymes are involved in the oxidations of numerous steroids, eicosanoids, alkaloids, and other endogenous substrates. These enzymes are also the major ones involved in the oxidation of potential toxicants and carcinogens such as those encountered among pollutants, solvents, and pesticides, as well as many natural products. A proper understanding of the basic mechanisms by which the P450 enzymes oxidize such compounds is important in developing rational strategies for the evaluation of the risks of these compounds.

Keywords

Human Liver Microsome Cytochrome P450 Enzyme Ethyl Carbamate Detoxication Product Human Cytochrome P450 Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • F. Peter Guengerich
    • 1
  • Yune-Fang Ueng
    • 1
  • Bok-Ryang Kim
    • 1
  • Sophie Langouet
    • 4
  • Brian Coles
    • 2
  • Rajkumar S. Iyer
    • 3
  • Ricarda Thier
    • 1
  • Thomas M. Harris
    • 3
  • Tsutomu Shimada
    • 1
  • Hiroshi Yamazaki
    • 1
  • Brian Ketterer
    • 2
  • Andre Guillouzo
    • 4
  1. 1.Department of Biochemistry and Center in Molecular ToxicologyUniversity College and Middlesex School of MedicineLondonUK
  2. 2.Cancer Research Campaign Molecular Toxicology GroupUniversity College and Middlesex School of MedicineLondonUK
  3. 3.Department of Chemistry and Center in Molecular ToxicologyVanderbilt University School of MedicineNashvilleUSA
  4. 4.Unité de Recherches HépatologiquesINSERM U49 Hôpital de PontchaillonRennes CédexFrance

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