Abstract
Halogenated benzenes are extensively used as solvents, fumigants and intermediates in the production of pesticides and dyes and therefore represent significant environmental contaminants (Hawley, 1971; US-EPA, 1985). It has been shown that biotransformation is necessary to exhibit toxicity (Brodie et al., 1971). Both 1,2-dichlorobenzene and its 1,4-isomer are metabolized by cytochrome P450 enzymes to an epoxide intermediate. This epoxide may either rearrange to produce phenols, hydrolyse to form dihydrodiols or conjugate with glutathione.
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Abbreviations
- DCB:
-
dichlorobenzene
- DCP:
-
dichlorophenol
- AA:
-
ascorbic acid
- GSH:
-
glutathione
References
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© 1996 Springer Science+Business Media New York
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Hissink, E., van Ommen, B., Bogaards, J.J., van Bladeren, P.J. (1996). Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzene. In: Snyder, R., et al. Biological Reactive Intermediates V. Advances in Experimental Medicine and Biology, vol 387. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9480-9_18
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DOI: https://doi.org/10.1007/978-1-4757-9480-9_18
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