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Studies on the Mechanism of Phototoxicity of BAY y 3118 and Other Quinolones

  • U. Schmidt
  • G. Schlüter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Abstract

The quinolone antibiotic BAY y 3118 is a photochemically labile compound, and irradiation with UV-A light leads to its rapid decomposition. In vivo, following oral drug administration to guinea pigs, irradiation of the animals not only results in a severe local phototoxicity, but also leads to systemic phototoxic reactions [1].

Keywords

Nalidixic Acid Skin Extract Phototoxic Reaction Oral Drug Administration Toxic Oxygen Radical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • U. Schmidt
    • 1
  • G. Schlüter
    • 1
  1. 1.FB ToxicologyBAYER AGWuppertalGermany

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