Studies on the Mechanism of Phototoxicity of BAY y 3118 and Other Quinolones
The quinolone antibiotic BAY y 3118 is a photochemically labile compound, and irradiation with UV-A light leads to its rapid decomposition. In vivo, following oral drug administration to guinea pigs, irradiation of the animals not only results in a severe local phototoxicity, but also leads to systemic phototoxic reactions .
KeywordsNalidixic Acid Skin Extract Phototoxic Reaction Oral Drug Administration Toxic Oxygen Radical
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