Summary
Fibroblasts release low amounts of reactive oxygen intermediates (ROIs) upon contact with appropriate stimuli, which have regulatory functions in inter- and intracellular signal transduction. Ca2+/calmodulin are involved in the activation process of the ROI-generating system. A rise of intracellular Ca2+ is necessary, but not sufficient to trigger the release of ROIs. As a second signal, protein phosphorylation seems to be involved in the activation process.
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Meier, B. (1996). Regulation of the Superoxide Releasing System in Human Fibroblasts. In: Snyder, R., et al. Biological Reactive Intermediates V. Advances in Experimental Medicine and Biology, vol 387. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9480-9_15
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DOI: https://doi.org/10.1007/978-1-4757-9480-9_15
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