Regulation of the Superoxide Releasing System in Human Fibroblasts

  • Beate Meier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)


Fibroblasts release low amounts of reactive oxygen intermediates (ROIs) upon contact with appropriate stimuli, which have regulatory functions in inter- and intracellular signal transduction. Ca2+/calmodulin are involved in the activation process of the ROI-generating system. A rise of intracellular Ca2+ is necessary, but not sufficient to trigger the release of ROIs. As a second signal, protein phosphorylation seems to be involved in the activation process.


Human Fibroblast Platelet Activate Factor Okadaic Acid Intracellular Signal Transduction Reactive Oxygen Intermediate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Meier, B., H. H. Radeke, S. Selle, M. Younes, H. Sies, K. Resch and G. G. Habermehl (1989) Biochem. J. 263, 539–545.PubMedGoogle Scholar
  2. 2.
    Meier, B., H.H. Radeke, S. Selle, H.-H. Raspe, H. Sies, K. Resch and G.G. Habermehl (1990) Free. Rad. Res. Commun. 8, 149–160.CrossRefGoogle Scholar
  3. 3.
    Meier, B., S. Selle, H.H. Radeke, G.G. Habermehl, K. Resch and H. Sies (1990) Biol. Chem. Hoppe-Seyler. 371, 1021–1025., 1990.PubMedCrossRefGoogle Scholar
  4. 4.
    Meier, B., A.R. Cross, J.T. Hanock, F.J. Kaup and O.T.G. Jones (1991) Biochem J. 275, 241–245.PubMedGoogle Scholar
  5. 5.
    Meier, B., A.J. Jesaitis, A. Emmendörfer, J. Roesler and M.T. Quinn (1993) Biochem. J. 289, 481–486.PubMedGoogle Scholar
  6. 6.
    Emmendörfer, A., J. Roesler, J. Eisner, E. Raeder, M.-L. Lohmann-Mathes and B. Meier (1993) Eur. J. Haematol. 51, 223–227.CrossRefGoogle Scholar
  7. 7.
    Jones, S.A., J.D. Wood, M.J. Coffey and O.T.G. Jones (1994) FEBS Lett. 355, 178–182.PubMedCrossRefGoogle Scholar
  8. 8.
    McCord, J. M. and I. Fridovich (1969) J. Biol. Chem. 244, 6049–6055.PubMedGoogle Scholar
  9. 9.
    Root, R.K., J. Metcalf, N. Oshino and B. Chance (1975) J. Clin. Invest. 55, 945–955.PubMedCrossRefGoogle Scholar
  10. 10.
    Cross, A.R. (1990) Free Rad. Biol. Med. 8, 71–93.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Beate Meier
    • 1
  1. 1.Chemisches InstitutTierärztliche Hochschule HannoverHannoverGermany

Personalised recommendations