New Biological Reactive Intermediates
Metabolic activation of benzene rings as well as that of many aromatic heterocycles such as furans generally involves the intermediate formation of arene oxides as electrophilic reactive metabolites. Much less was known until very recently about the metabolic oxidative activation of thiophene derivatives (Rance, 1989). A first report on the metabolism of thiophene itself in rats has shown the formation of thiophene-derived mercapturates in urine and proposed the intermediate formation of a thiophene epoxide (Bray et al., 1971). More recently, it has been shown that the major oxidized metabolites of several 2-aroylthiophenes, such as tienilic acid (Mansuy et al., 1984) were derived from 5-hydroxylation of their thiophene ring (Neau et al., 1990).
KeywordsHepatitis Benzene Glutathione Catalysis Adduct
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